The actions of prostaglandins and their interactions with angiotensin II in the isolated perfused human placental cotyledon

D. G. Glance, M. G. Elder, Leslie Myatt

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The prostaglandins PGE1, PGE2, PGD2, PGF, U46619 and 6β-PGI1 were administered as bolus injections both separately and in combination with angiotensin II into the fetal circulation of isolated human placental cotyledons perfused in vitro. PGF and PGD2 caused small dose-dependent increases in fetal perfusion pressure when compared with U46619 which acted as an extremely potent vasoconstrictor of the fetal-placental vasculature. PGE1 caused very small dose-dependent decreases in fetal perfusion pressure when injected on its own. In combination with angiotensin II, PGE1, PGD2 and 6β-PGI1 caused significant, dose-related attenuations of the angiotensin II vasoconstrictive response whereas PGE2, PGF and U46619 potentiated the response. Injections of angiotensin II after the infusion of indo-methacin into the fetal circulation resulted in a potentiation of angiotensin II induced vasoconstriction. The results indicate that prostaglandins exert their effects on the fetal-placental circulation by modulating the actions of angiotensin II.

Original languageEnglish (US)
Pages (from-to)488-494
Number of pages7
JournalBritish Journal of Obstetrics and Gynaecology
Volume93
Issue number5
StatePublished - May 1986
Externally publishedYes

Fingerprint

Cotyledon
Angiotensin II
Prostaglandins
Prostaglandin D2
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Dinoprost
Alprostadil
Dinoprostone
Oxyphenonium
Perfusion
Placental Circulation
Pressure
Injections
Vasoconstrictor Agents
Vasoconstriction

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The actions of prostaglandins and their interactions with angiotensin II in the isolated perfused human placental cotyledon. / Glance, D. G.; Elder, M. G.; Myatt, Leslie.

In: British Journal of Obstetrics and Gynaecology, Vol. 93, No. 5, 05.1986, p. 488-494.

Research output: Contribution to journalArticle

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