Abstract
Ethanol‐dependent mice were treated with the 5‐HT3 antagonist MDL 72222 after withdrawal from ethanol. Treatment with unit doses (0, 5.6, 10, and 17.0 mg/kg) of MDL 72222 at 0, 4, and 7 hr after withdrawal dose‐dependently exacerbated the severity of ethanol withdrawal seizures. Treatment with a single dose (17 mg/kg) of MDL 72222 at 5 hr after withdrawal also exacerbated the severity of ethanol withdrawal seizures. Ethanol naive mice treated with MDL 72222 (56 mg/kg) did not display any seizures. Treatment with another 5‐HT3 antagonist, ICS 205‐930 (23 and 46 mg/kg), or the 5‐ HT2 receptor antagonist ketanserin, did not affect ethanol withdrawal seizures. The findings suggest MDL 72222 selectively enhances sensitivity to withdrawal seizures following chronic ethanol exposure.
Original language | English (US) |
---|---|
Pages (from-to) | 410-414 |
Number of pages | 5 |
Journal | Alcoholism: Clinical and Experimental Research |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1994 |
Externally published | Yes |
Keywords
- 5‐HT Antagonists
- Alcohol Dependence
- Drug Withdrawal Seizures
- Serotonin
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
- Psychiatry and Mental health