The 17-Gene Genomic Prostate Score Assay Predicts Outcome After Radical Prostatectomy Independent of PTEN Status

Cristina Magi-Galluzzi, Sudhir Isharwal, Sara M. Falzarano, Athanasios Tsiatis, Anne Dee, Tara Maddala, Dejan Knezevic, Phillip G. Febbo, Jeffrey Lawrence, Eric A. Klein

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Abstract

Objective: To compare the ability of loss of phosphatase and tensin homolog (PTEN) and Genomic prostate score assay (GPS) in predicting the biochemical-recurrence (BCR) and clinical-recurrence (CR) after radical prostatectomy (RP) for clinically localized prostate cancer (PCa). Methods: Three hundred seventy seven patients with and without CR were retrospectively selected by stratified cohort sampling design from RP database. PTEN status (by immunohistochemistry [IHC] and fluorescence in situ hybridization [FISH]) and GPS results were determined for RP specimens. BCR was defined as Prostate Specific Antigen (PSA) ≥ 0.2 ng/mL or initiation of salvage therapy for a rising PSA. CR was defined as local recurrence and/or distant metastases. Results: Baseline mean age, PSA, and GPS score for the cohort were 61.1 years, 8 ng/dL, and 32.8. PTEN loss was noted in 38% patients by FISH and 25% by IHC. The concordance between FISH and IHC for PTEN loss was 66% (Kappa coefficient 0.278; P <.001). On univariable analysis, loss of PTEN by FISH or IHC was associated with BCR and CR (P <.05). However, after adjusting for GPS results, PTEN loss was not a significant predictor for CR or BCR (P >.1). The GPS result remained strongly associated with CR and BCR after adjusting for PTEN status (P <.001). PTEN status and GPS results only weakly correlated. GPS was widely distributed regardless of PTEN status indicating the biological heterogeneity of PCa even in PTEN-deficient cases. Conclusion: GPS is a significant predictor of aggressive PCa, independent of PTEN status. After adjustment for GPS results, PTEN was not independently associated with recurrence for PCa.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalUrology
Volume121
DOIs
StatePublished - Nov 1 2018
Externally publishedYes

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ASJC Scopus subject areas

  • Urology

Cite this

Magi-Galluzzi, C., Isharwal, S., Falzarano, S. M., Tsiatis, A., Dee, A., Maddala, T., Knezevic, D., Febbo, P. G., Lawrence, J., & Klein, E. A. (2018). The 17-Gene Genomic Prostate Score Assay Predicts Outcome After Radical Prostatectomy Independent of PTEN Status. Urology, 121, 132-138. https://doi.org/10.1016/j.urology.2018.07.018