Abstract
Studies are reported on the cyclization of (ω-hydroxy-β-hydroxyalkyl)cobaloximes (1, 2 and 3) to form 5,6 and 7-membered ring cyclic ethers (4, 5 and 6). Reversible cyclization and eventual irreversible alkene decomplexation (to form 7, 8 and 9) varied as a function of ring size. The practical consequence is that cyclizations to form 5 and 6 membered rings are feasible whereas formation of a 7 membered ring is not.
Original language | English (US) |
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Pages (from-to) | 3447-3448 |
Number of pages | 2 |
Journal | Tetrahedron Letters |
Volume | 39 |
Issue number | 21 |
DOIs | |
State | Published - May 21 1998 |
Externally published | Yes |
Keywords
- Carbonium ions
- Cobalt and compounds
- Cyclization
- Ethers
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry