Testosterone increases acetylcholine receptor number in the “levator ani” muscle of the rat

William V. Bleisch, Allan L. Harrelson, Victoria N. Luine

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The “levator ani” muscle of male rats provides a neuromuscular system in which both the muscle and its motoneurons have high levels of androgen receptors. Two weeks of castration caused a 48% loss of acetylcholine receptors in this muscle. One week of testosterone propionate injections initiated one week after castration increased receptor number by 27% over untreated castrate levels. These changes paralleled changes in muscle protein content. In contrast, castration and testosterone treatments of castrates had no effect on total, Triton X‐100‐extractable acetylcholinesterase activity. This system may provide a useful model of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Neurobiology
Volume13
Issue number2
DOIs
StatePublished - Mar 1982
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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