Testosterone increases acetylcholine receptor number in the “levator ani” muscle of the rat

William V. Bleisch, Allan L. Harrelson, Victoria N. Luine

    Research output: Contribution to journalArticle

    34 Scopus citations

    Abstract

    The “levator ani” muscle of male rats provides a neuromuscular system in which both the muscle and its motoneurons have high levels of androgen receptors. Two weeks of castration caused a 48% loss of acetylcholine receptors in this muscle. One week of testosterone propionate injections initiated one week after castration increased receptor number by 27% over untreated castrate levels. These changes paralleled changes in muscle protein content. In contrast, castration and testosterone treatments of castrates had no effect on total, Triton X‐100‐extractable acetylcholinesterase activity. This system may provide a useful model of synaptic plasticity.

    Original languageEnglish (US)
    Pages (from-to)153-161
    Number of pages9
    JournalJournal of Neurobiology
    Volume13
    Issue number2
    DOIs
    StatePublished - Mar 1982

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Cellular and Molecular Neuroscience

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