Testosterone increases acetylcholine receptor number in the 'levator ani' muscle of the rat

W. V. Bleisch, Allan Harrelson, V. N. Luine

Research output: Contribution to journalArticle

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Abstract

The 'levator ani' muscle of male rats provides a neuromuscular system in which both the muscle and its motoneurons have high levels of androgen receptors. Two weeks of castration caused a 48% loss of acetylcholine receptors in this muscle. One week of testosterone propionate injections initiated one week after castration increased receptor number by 27% over untreated castrated levels. These changes paralleled changes in muscle protein content. In contrast, castration and testosterone treatments of castrates had no effect on total, Triton X-100-extractable acetylcholinesterase activity. This system may provide a useful model of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Neurobiology
Volume13
Issue number2
Publication statusPublished - 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

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