Testosterone and dihydrotestosterone differentially improve cognition in aged female mice

Ted S. Benice, Jacob Raber

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Compared with age-matched male mice, female mice experience a more severe age-related cognitive decline (ACD). Since androgens are less abundant in aged female mice compared with aged male mice, androgen supplementation may enhance cognition in aged female mice. To test this, we assessed behavioral performance on a variety of tasks in 22- to 24-mo-old gonadally intact female mice treated for 6 wk with silastic capsules containing either testosterone (T) or dihydrotestosterone (DHT) or empty capsules (placebo). Compared with placebo-treated mice, spatial memory retention in the water maze was enhanced by testosterone treatment, but not DHT treatment. In contrast, DHT treatment improved passive avoidance (PA) retention, while T treatment only did so marginally. These data support that androgen supplementation in old female mice improves cognitive performance differentially depending upon the type of hormone treatment and cognitive task.

Original languageEnglish (US)
Pages (from-to)479-485
Number of pages7
JournalLearning and Memory
Volume16
Issue number8
DOIs
StatePublished - Aug 2009

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Dihydrotestosterone
Cognition
Testosterone
Androgens
Capsules
Placebos
Therapeutics
Hormones
Water

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. / Benice, Ted S.; Raber, Jacob.

In: Learning and Memory, Vol. 16, No. 8, 08.2009, p. 479-485.

Research output: Contribution to journalArticle

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