Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus

Benjamin J. Burwitz, Helen L. Wu, Jason S. Reed, Katherine B. Hammond, Laura P. Newman, Benjamin N. Bimber, Francesca A. Nimiyongskul, Enrique J. Leon, Nicholas J. Maness, Thomas C. Friedrich, Masaru Yokoyama, Hironori Sato, Tetsuro Matano, David H. O'Connor, Jonah B. Sacha

Research output: Contribution to journalArticle

Abstract

Compensatory mutations offset fitness defects resulting from CD8+ T lymphocyte (CD8TL)-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag181-189CM9 CD8TL escape-associated compensatory mutations in simian immunodeficiency virus (SIV)-infected macaques. Preexisting compensatory mutations did not result in acute-phase escape of the SIVmac239 CD8TL epitope Gag181-189CM9 and instead required a tertiary mutation for stabilization in the absence of Gag181-189CM9 escape mutations. Therefore, transmitted compensatory mutations do not necessarily predict rapid CD8TL escape.

Original languageEnglish (US)
Pages (from-to)3598-3604
Number of pages7
JournalJournal of virology
Volume88
Issue number6
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Burwitz, B. J., Wu, H. L., Reed, J. S., Hammond, K. B., Newman, L. P., Bimber, B. N., Nimiyongskul, F. A., Leon, E. J., Maness, N. J., Friedrich, T. C., Yokoyama, M., Sato, H., Matano, T., O'Connor, D. H., & Sacha, J. B. (2014). Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus. Journal of virology, 88(6), 3598-3604. https://doi.org/10.1128/JVI.03304-13