Terminal differentiation of myeloleukemic M1 cells induced by IL-6: Role of endogenous interferon

Y. Gothelf, J. Raber, L. Chen, A. Schattner, J. Chebath, M. Revel

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

During terminal differentiation of myeloleukemic M1 cells triggered by IL- 6, an induction of IFN-activated genes, such as IRF-1, class I MHC, and (2'- 5')-A synthetase, is observed. Antibodies to murine type I IFN, inhibit most (2'-5')-A synthetase induction but do not inhibit IL-6-induced growth-arrest and differentiation. IL-6 induction of (2'-5')-A synthetase subforms, however, differs from that of IFN. IL-6 in fact induces a cell surface form of (2'-5')-A synthetase that is not induced by IFN.

Original languageEnglish (US)
Pages (from-to)369-375
Number of pages7
JournalLymphokine and Cytokine Research
Volume10
Issue number5
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Immunology
  • Hematology

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