During terminal differentiation of myeloleukemic M1 cells triggered by IL- 6, an induction of IFN-activated genes, such as IRF-1, class I MHC, and (2'- 5')-A synthetase, is observed. Antibodies to murine type I IFN, inhibit most (2'-5')-A synthetase induction but do not inhibit IL-6-induced growth-arrest and differentiation. IL-6 induction of (2'-5')-A synthetase subforms, however, differs from that of IFN. IL-6 in fact induces a cell surface form of (2'-5')-A synthetase that is not induced by IFN.
|Original language||English (US)|
|Number of pages||7|
|Journal||Lymphokine and Cytokine Research|
|State||Published - 1991|
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