Terminal differentiation of myeloleukemic M1 cells induced by IL-6: Role of endogenous interferon

Y. Gothelf, Jacob Raber, L. Chen, A. Schattner, J. Chebath, M. Revel

Research output: Contribution to journalArticle

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Abstract

During terminal differentiation of myeloleukemic M1 cells triggered by IL- 6, an induction of IFN-activated genes, such as IRF-1, class I MHC, and (2'- 5')-A synthetase, is observed. Antibodies to murine type I IFN, inhibit most (2'-5')-A synthetase induction but do not inhibit IL-6-induced growth-arrest and differentiation. IL-6 induction of (2'-5')-A synthetase subforms, however, differs from that of IFN. IL-6 in fact induces a cell surface form of (2'-5')-A synthetase that is not induced by IFN.

Original languageEnglish (US)
Pages (from-to)369-375
Number of pages7
JournalLymphokine and Cytokine Research
Volume10
Issue number5
StatePublished - 1991
Externally publishedYes

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Ligases
Interferons
Interleukin-6
Antibodies
Growth
Genes

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Terminal differentiation of myeloleukemic M1 cells induced by IL-6 : Role of endogenous interferon. / Gothelf, Y.; Raber, Jacob; Chen, L.; Schattner, A.; Chebath, J.; Revel, M.

In: Lymphokine and Cytokine Research, Vol. 10, No. 5, 1991, p. 369-375.

Research output: Contribution to journalArticle

Gothelf, Y, Raber, J, Chen, L, Schattner, A, Chebath, J & Revel, M 1991, 'Terminal differentiation of myeloleukemic M1 cells induced by IL-6: Role of endogenous interferon', Lymphokine and Cytokine Research, vol. 10, no. 5, pp. 369-375.
Gothelf, Y. ; Raber, Jacob ; Chen, L. ; Schattner, A. ; Chebath, J. ; Revel, M. / Terminal differentiation of myeloleukemic M1 cells induced by IL-6 : Role of endogenous interferon. In: Lymphokine and Cytokine Research. 1991 ; Vol. 10, No. 5. pp. 369-375.
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