Tenting volume

Three-dimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair

Frederick (Fred) Tibayan, Ariane Wilson, David T M Lai, Tomasz A. Timek, Paul Dagum, Filiberto Rodriguez, Mary K. Zasio, David Liang, George T. Daughters, Neil B. Ingels, D. Craig Miller

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background and aim of the study: Functional mitral regurgitation (FMR) often complicates dilated cardiomyopathy (DCM), and portends a poor prognosis. Debate over the optimal treatment continues, under-scoring the present incomplete understanding of the patho-anatomic mechanisms of this disease. Studies of mitral tenting volume and tenting area, and echocardiographic measures of abnormal apical systolic leaflet geometry have linked mitral leaflet deformation with subvalvular left ventricular (LV) remodeling in chronic ischemic MR. The relative contributions of annular versus subvalvular remodeling in FMR due to DCM are less dear. Here, the validity of 3-D measurement of mitral deformation, tenting volume, as a correlate of MR in DCM, was tested. The ability of annular and subvalvular remodeling to predict mitral deformation was then determined. Methods: Eight sheep underwent placement of radiopaque markers on the mitral annulus and leaflets. Global LV, annular and subvalvular geometry, as well as mitral tenting height, area and volume were calculated before (Control) and after the development of pacing-induced cardiomyopathy and MR (DCM). Multivariable regression determined which measure of mitral deformation was the best predictor of MR. Regression analysis was also used to find geometric predictors of mitral tenting volume. Results: In a multivariable analysis, mitral tenting volume was the only independent predictor of severity of MR (r2 = 0.79, standard error of estimate (SEE) = 0.58). Increased tenting volume correlated best with increased mitral annular septal-lateral diameter (r2 = 0.67, SEE = 0.72). Conclusion: The 3-D tenting volume correlates best with severity of FMR. Mitral deformation (increased tenting volume) observed in DCM is predicted by annular dilation, but not by subvalvular LV remodeling. These data support the use of an undersized annuloplasty in DCM complicated by FMR, and may guide the rational design of new therapies for this vexing disease.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Heart Valve Disease
Volume16
Issue number1
StatePublished - Jan 2007
Externally publishedYes

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Dilated Cardiomyopathy
Mitral Valve Insufficiency
Ventricular Remodeling
Cardiomyopathies
Dilatation
Sheep
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tenting volume : Three-dimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair. / Tibayan, Frederick (Fred); Wilson, Ariane; Lai, David T M; Timek, Tomasz A.; Dagum, Paul; Rodriguez, Filiberto; Zasio, Mary K.; Liang, David; Daughters, George T.; Ingels, Neil B.; Miller, D. Craig.

In: Journal of Heart Valve Disease, Vol. 16, No. 1, 01.2007, p. 1-7.

Research output: Contribution to journalArticle

Tibayan, FF, Wilson, A, Lai, DTM, Timek, TA, Dagum, P, Rodriguez, F, Zasio, MK, Liang, D, Daughters, GT, Ingels, NB & Miller, DC 2007, 'Tenting volume: Three-dimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair', Journal of Heart Valve Disease, vol. 16, no. 1, pp. 1-7.
Tibayan, Frederick (Fred) ; Wilson, Ariane ; Lai, David T M ; Timek, Tomasz A. ; Dagum, Paul ; Rodriguez, Filiberto ; Zasio, Mary K. ; Liang, David ; Daughters, George T. ; Ingels, Neil B. ; Miller, D. Craig. / Tenting volume : Three-dimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair. In: Journal of Heart Valve Disease. 2007 ; Vol. 16, No. 1. pp. 1-7.
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abstract = "Background and aim of the study: Functional mitral regurgitation (FMR) often complicates dilated cardiomyopathy (DCM), and portends a poor prognosis. Debate over the optimal treatment continues, under-scoring the present incomplete understanding of the patho-anatomic mechanisms of this disease. Studies of mitral tenting volume and tenting area, and echocardiographic measures of abnormal apical systolic leaflet geometry have linked mitral leaflet deformation with subvalvular left ventricular (LV) remodeling in chronic ischemic MR. The relative contributions of annular versus subvalvular remodeling in FMR due to DCM are less dear. Here, the validity of 3-D measurement of mitral deformation, tenting volume, as a correlate of MR in DCM, was tested. The ability of annular and subvalvular remodeling to predict mitral deformation was then determined. Methods: Eight sheep underwent placement of radiopaque markers on the mitral annulus and leaflets. Global LV, annular and subvalvular geometry, as well as mitral tenting height, area and volume were calculated before (Control) and after the development of pacing-induced cardiomyopathy and MR (DCM). Multivariable regression determined which measure of mitral deformation was the best predictor of MR. Regression analysis was also used to find geometric predictors of mitral tenting volume. Results: In a multivariable analysis, mitral tenting volume was the only independent predictor of severity of MR (r2 = 0.79, standard error of estimate (SEE) = 0.58). Increased tenting volume correlated best with increased mitral annular septal-lateral diameter (r2 = 0.67, SEE = 0.72). Conclusion: The 3-D tenting volume correlates best with severity of FMR. Mitral deformation (increased tenting volume) observed in DCM is predicted by annular dilation, but not by subvalvular LV remodeling. These data support the use of an undersized annuloplasty in DCM complicated by FMR, and may guide the rational design of new therapies for this vexing disease.",
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T2 - Three-dimensional assessment of geometric perturbations in functional mitral regurgitation and implications for surgical repair

AU - Tibayan, Frederick (Fred)

AU - Wilson, Ariane

AU - Lai, David T M

AU - Timek, Tomasz A.

AU - Dagum, Paul

AU - Rodriguez, Filiberto

AU - Zasio, Mary K.

AU - Liang, David

AU - Daughters, George T.

AU - Ingels, Neil B.

AU - Miller, D. Craig

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