Temporal trends in syphilis and gonorrhea incidences in Guangdong Province, China

Nicholas X. Tan, Grace X. Tan, Li Gang Yang, Bin Yang, Kimberly A. Powers, Michael E. Emch, Joseph D. Tucker

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The high burden of syphilis in China presents a unique opportunity to examine temporal trends. This study used wavelet transformation and Fourier analysis to assess the presence of temporal oscillations in the incidence of syphilis among adults, gonorrhea, and congenital syphilis over 11 years in China's largest province. This study found a significant annual oscillation trend in the incidence of adult syphilis, consistent with a peak during July-September, which was 4-fold higher than the trough, which occurred during January-March. A similar but dampened trend was observed in the incidence of gonorrhea, and no trend was observed for the incidence of congenital syphilis. Further research on the temporal oscillation of the incidence of syphilis is needed.

Original languageEnglish (US)
Pages (from-to)426-430
Number of pages5
JournalJournal of Infectious Diseases
Issue number3
StatePublished - 2014
Externally publishedYes


  • Fourier transform
  • disease dynamics
  • gonorrhea
  • immunity
  • oscillation
  • syphilis
  • wavelet

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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