Temporal relationship between antitumor necrosis factor-α antibody therapy and recrudescence of head and neck squamous cell carcinoma

Samuel H. Engel, Timothy Hullar, Douglas R. Adkins, Wade L. Thorstad, John B. Sunwoo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF)-α inhibitors have been used effectively to treat rheumatoid arthritis and inflammatory bowel disease. Although the role of TNF-α in tumor development is not well understood, an increased risk of malignancies with anti-TNF-α therapy has been suggested. We report an instructive case of a patient, treated for Crohn's disease with infliximab, who presented with a neck abscess diagnosed to be head and neck squamous cell carcinoma. The patient's clinical course illustrates a temporal relationship between reappearance of his cancer after a complete response to therapy and the resumption of infliximab for worsening Crohn's disease.

Original languageEnglish (US)
Pages (from-to)450-452
Number of pages3
JournalLaryngoscope
Volume118
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Necrosis
Tumor Necrosis Factor-alpha
Recurrence
Crohn Disease
Antibodies
Neoplasms
Inflammatory Bowel Diseases
Abscess
Rheumatoid Arthritis
Neck
Therapeutics
Carcinoma, squamous cell of head and neck
Infliximab

Keywords

  • Abscess
  • Head and neck cancer
  • Immune
  • Immune system
  • Infliximab
  • Malignancy
  • Remicade
  • Squamous cell carcinoma
  • TNF-α inhibitors
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Temporal relationship between antitumor necrosis factor-α antibody therapy and recrudescence of head and neck squamous cell carcinoma. / Engel, Samuel H.; Hullar, Timothy; Adkins, Douglas R.; Thorstad, Wade L.; Sunwoo, John B.

In: Laryngoscope, Vol. 118, No. 3, 03.2008, p. 450-452.

Research output: Contribution to journalArticle

Engel, Samuel H. ; Hullar, Timothy ; Adkins, Douglas R. ; Thorstad, Wade L. ; Sunwoo, John B. / Temporal relationship between antitumor necrosis factor-α antibody therapy and recrudescence of head and neck squamous cell carcinoma. In: Laryngoscope. 2008 ; Vol. 118, No. 3. pp. 450-452.
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