Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy

D. E. Burdette, S. Y. Sakurai, T. R. Henry, Donald (Don) Ross, P. B. Pennell, K. A. Frey, J. C. Sackellares, R. L. Albin

Research output: Contribution to journalArticle

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Abstract

PET-demonstrated decreases in [nC]flumazenil binding occur in anterior mesial temporal structures on the side of epileptogenesis in unilateral mesial temporal lobe epilepsy. We performed quantitative autoradiography on anterior mesial and lateral temporal specimens from 11 subjects with unilateral mesial temporal lobe epilepsy and six neurologically normal controls to identify the predominant in vitro correlates of the decreased [nC]flumazenil binding. In anterior mesial temporal regions exhibiting the greatest neuronal cell loss, decreases in agonist and antagonist binding to type 1 and 2 (central) benzodiazepine binding sites were highly correlated with neuronal cell counts. Cell loss and decreased binding were particularly prominent in the lateral portion of hippocampal region CA1, adjacent to CA2. Lateral temporal central benzodiazepine binding was diffusely increased, achieving statistical significance in cortical laminae V and VI. These findings suggest that the predominant source of PET-demonstrated decreases in [nC]flumazenil binding in mesial temporal epilepsy is hippocampal sclerosis, rather than down- regulation of central benzodiazepine binding sites on surviving hippocampal neurons.

Original languageEnglish (US)
Pages (from-to)934-941
Number of pages8
JournalNeurology
Volume45
Issue number5
StatePublished - 1995
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Temporal Lobe
Benzodiazepines
Flumazenil
Binding Sites
Hippocampal CA1 Region
Sclerosis
Autoradiography
Epilepsy
Down-Regulation
Cell Count
Neurons

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Burdette, D. E., Sakurai, S. Y., Henry, T. R., Ross, D. D., Pennell, P. B., Frey, K. A., ... Albin, R. L. (1995). Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. Neurology, 45(5), 934-941.

Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. / Burdette, D. E.; Sakurai, S. Y.; Henry, T. R.; Ross, Donald (Don); Pennell, P. B.; Frey, K. A.; Sackellares, J. C.; Albin, R. L.

In: Neurology, Vol. 45, No. 5, 1995, p. 934-941.

Research output: Contribution to journalArticle

Burdette, DE, Sakurai, SY, Henry, TR, Ross, DD, Pennell, PB, Frey, KA, Sackellares, JC & Albin, RL 1995, 'Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy', Neurology, vol. 45, no. 5, pp. 934-941.
Burdette DE, Sakurai SY, Henry TR, Ross DD, Pennell PB, Frey KA et al. Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. Neurology. 1995;45(5):934-941.
Burdette, D. E. ; Sakurai, S. Y. ; Henry, T. R. ; Ross, Donald (Don) ; Pennell, P. B. ; Frey, K. A. ; Sackellares, J. C. ; Albin, R. L. / Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. In: Neurology. 1995 ; Vol. 45, No. 5. pp. 934-941.
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