Temperature Dependence of Ethanol Depression in Mice: Dose Response

Deborah A. Finn, Peter J. Syapin, Marina Bejanian, Brenda L. Jones, Ronald L. Alkana

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Manipulation of body temperature during intoxication significantly alters brain sensitivity to ethanol. The current study tested the generality of this effect within the hypnotic dose range. Drug naive, male C57BL/6J mice were injected with 3.2, 3.6, or 4.0 g/kg ethanol (20% w/v) and were exposed to 1 of 7 designated temperatures from 13° to 34°C to manipulate body temperature during intoxication. Rectal temperature at return of righting reflex (RORR) was significantly, positively correlated with loss of righting reflex (LORR) duration and significantly, negatively correlated with blood ethanol concentration (BEC) at RORR at all three doses. These results indicate that increasing body temperature during intoxication increased ethanol sensitivity in C57 mice at all three doses tested and demonstrate the generality of temperature dependence across hypnotic doses in these animals. Interestingly, the LORR duration was dose‐dependent at each ambient temperature, but the degree of body temperature change and the BEC at RORR were not dose‐dependent. Overall, these results emphasize the importance of body temperature as a variable in ethanol research.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume18
Issue number2
DOIs
StatePublished - Apr 1994

Keywords

  • Body Temperature
  • Ethanol
  • Ethanol Concentration
  • Hypnotic Dose Response
  • Loss of Righting Reflex (LORR) Duration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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