Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity

Samir N. Patel; Ranjodh Singh; Karyn E. Jonas; Susan Ostmo; Mrinali P. Gupta; J. Peter Campbell; Michael Chiang; R. V.Paul Chan; Michael F. Chiang; Susan Ostmo; Kemal Sonmez; J. Peter Campbell; R. V.Paul Chan; Karyn Jonas; Jason Horowitz; Osode Coki; Cheryl Ann Eccles; Leora Sarna; Anton Orlin; Audina Berrocal; Catherin Negron; Kimberly Drenser; Kristi Cumming; Tammy Osentoski; Tammy Check; Mary Zajechowski; Thomas Lee; Evan Kruger; Kathryn McGovern; Charles Simmons; Raghu Murthy; Sharon Galvis; Jerome Rotter; Ida Chen; Xiaohui Li; Kent Taylor; Kaye Roll; Jayashree Kalpathy-Cramer; Deniz Erdogmus; Stratis Ioannidis; Maria Ana Martinez-Castellanos; Samantha Salinas-Longoria; Rafael Romero; Andrea Arriola; Francisco Olguin-Manriquez; Miroslava Meraz-Gutierrez; Carlos M. Dulanto-Reinoso; Cristina Montero-Mendoza

doi:10.1016/j.oret.2017.04.001

Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity

Samir N. Patel, Ranjodh Singh, Karyn E. Jonas, Susan Ostmo, Mrinali P. Gupta, J. Peter Campbell, Michael Chiang, R. V.Paul Chan, Michael F. Chiang, Susan Ostmo, Kemal Sonmez, J. Peter Campbell, R. V.Paul Chan, Karyn Jonas, Jason Horowitz, Osode Coki, Cheryl Ann Eccles, Leora Sarna, Anton Orlin, Audina BerrocalCatherin Negron, Kimberly Drenser, Kristi Cumming, Tammy Osentoski, Tammy Check, Mary Zajechowski, Thomas Lee, Evan Kruger, Kathryn McGovern, Charles Simmons, Raghu Murthy, Sharon Galvis, Jerome Rotter, Ida Chen, Xiaohui Li, Kent Taylor, Kaye Roll, Jayashree Kalpathy-Cramer, Deniz Erdogmus, Stratis Ioannidis, Maria Ana Martinez-Castellanos, Samantha Salinas-Longoria, Rafael Romero, Andrea Arriola, Francisco Olguin-Manriquez, Miroslava Meraz-Gutierrez, Carlos M. Dulanto-Reinoso, Cristina Montero-Mendoza

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To determine the accuracy of image-based diagnosis for stage 4 or worse retinopathy of prematurity (ROP) disease. Design: Prospective cohort study. Participants: We prospectively obtained data, from 8 major ROP centers, for 1220 eye examinations from 230 infants. Methods: An ophthalmologist at each center provided a clinical diagnosis using indirect ophthalmoscopy. Wide-angle retinal images (RetCam; Clarity Medical Systems, Pleasanton, CA) were then obtained, and these were independently read by 2 ROP experts using a web-based system for an image-based diagnosis. Main Outcome Measures: Sensitivity and specificity of image-based diagnosis from the ROP experts were calculated using the clinical diagnosis as the reference standard. Results: Of 1220 examinations, 28 (2%) had a clinical diagnosis of stage 4 or worse. Sensitivity and specificity for stage 4 or worse disease were 75% and 99% for expert 1, and 86% and 99% for expert 2. Sensitivity and specificity for the detection of stage 5 disease were 69% and 99% for both experts. Conclusions: There are inconsistencies in the accuracy of image-based diagnosis of stage 4 and stage 5 ROP when compared with the clinical diagnosis.

Original language	English (US)
Pages (from-to)	59-64
Number of pages	6
Journal	Ophthalmology Retina
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.oret.2017.04.001
State	Published - 2018

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.oret.2017.04.001

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Patel, S. N., Singh, R., Jonas, K. E., Ostmo, S., Gupta, M. P., Campbell, J. P., Chiang, M., Chan, R. V. P., Chiang, M. F., Ostmo, S., Sonmez, K., Campbell, J. P., Chan, R. V. P., Jonas, K., Horowitz, J., Coki, O., Eccles, C. A., Sarna, L., Orlin, A., ... Montero-Mendoza, C. (2018). Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity. Ophthalmology Retina, 2(1), 59-64. https://doi.org/10.1016/j.oret.2017.04.001

Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity. / Patel, Samir N.; Singh, Ranjodh; Jonas, Karyn E.; Ostmo, Susan; Gupta, Mrinali P.; Campbell, J. Peter; Chiang, Michael; Chan, R. V.Paul; Chiang, Michael F.; Ostmo, Susan; Sonmez, Kemal; Campbell, J. Peter; Chan, R. V.Paul; Jonas, Karyn; Horowitz, Jason; Coki, Osode; Eccles, Cheryl Ann; Sarna, Leora; Orlin, Anton; Berrocal, Audina; Negron, Catherin; Drenser, Kimberly; Cumming, Kristi; Osentoski, Tammy; Check, Tammy; Zajechowski, Mary; Lee, Thomas; Kruger, Evan; McGovern, Kathryn; Simmons, Charles; Murthy, Raghu; Galvis, Sharon; Rotter, Jerome; Chen, Ida; Li, Xiaohui; Taylor, Kent; Roll, Kaye; Kalpathy-Cramer, Jayashree; Erdogmus, Deniz; Ioannidis, Stratis; Martinez-Castellanos, Maria Ana; Salinas-Longoria, Samantha; Romero, Rafael; Arriola, Andrea; Olguin-Manriquez, Francisco; Meraz-Gutierrez, Miroslava; Dulanto-Reinoso, Carlos M.; Montero-Mendoza, Cristina.

In: Ophthalmology Retina, Vol. 2, No. 1, 2018, p. 59-64.

Research output: Contribution to journal › Article › peer-review

Patel, SN, Singh, R, Jonas, KE, Ostmo, S, Gupta, MP, Campbell, JP, Chiang, M, Chan, RVP, Chiang, MF, Ostmo, S, Sonmez, K, Campbell, JP, Chan, RVP, Jonas, K, Horowitz, J, Coki, O, Eccles, CA, Sarna, L, Orlin, A, Berrocal, A, Negron, C, Drenser, K, Cumming, K, Osentoski, T, Check, T, Zajechowski, M, Lee, T, Kruger, E, McGovern, K, Simmons, C, Murthy, R, Galvis, S, Rotter, J, Chen, I, Li, X, Taylor, K, Roll, K, Kalpathy-Cramer, J, Erdogmus, D, Ioannidis, S, Martinez-Castellanos, MA, Salinas-Longoria, S, Romero, R, Arriola, A, Olguin-Manriquez, F, Meraz-Gutierrez, M, Dulanto-Reinoso, CM & Montero-Mendoza, C 2018, 'Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity', Ophthalmology Retina, vol. 2, no. 1, pp. 59-64. https://doi.org/10.1016/j.oret.2017.04.001

Patel, Samir N. ; Singh, Ranjodh ; Jonas, Karyn E. ; Ostmo, Susan ; Gupta, Mrinali P. ; Campbell, J. Peter ; Chiang, Michael ; Chan, R. V.Paul ; Chiang, Michael F. ; Ostmo, Susan ; Sonmez, Kemal ; Campbell, J. Peter ; Chan, R. V.Paul ; Jonas, Karyn ; Horowitz, Jason ; Coki, Osode ; Eccles, Cheryl Ann ; Sarna, Leora ; Orlin, Anton ; Berrocal, Audina ; Negron, Catherin ; Drenser, Kimberly ; Cumming, Kristi ; Osentoski, Tammy ; Check, Tammy ; Zajechowski, Mary ; Lee, Thomas ; Kruger, Evan ; McGovern, Kathryn ; Simmons, Charles ; Murthy, Raghu ; Galvis, Sharon ; Rotter, Jerome ; Chen, Ida ; Li, Xiaohui ; Taylor, Kent ; Roll, Kaye ; Kalpathy-Cramer, Jayashree ; Erdogmus, Deniz ; Ioannidis, Stratis ; Martinez-Castellanos, Maria Ana ; Salinas-Longoria, Samantha ; Romero, Rafael ; Arriola, Andrea ; Olguin-Manriquez, Francisco ; Meraz-Gutierrez, Miroslava ; Dulanto-Reinoso, Carlos M. ; Montero-Mendoza, Cristina. / Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity. In: Ophthalmology Retina. 2018 ; Vol. 2, No. 1. pp. 59-64.

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title = "Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity",

abstract = "Purpose: To determine the accuracy of image-based diagnosis for stage 4 or worse retinopathy of prematurity (ROP) disease. Design: Prospective cohort study. Participants: We prospectively obtained data, from 8 major ROP centers, for 1220 eye examinations from 230 infants. Methods: An ophthalmologist at each center provided a clinical diagnosis using indirect ophthalmoscopy. Wide-angle retinal images (RetCam; Clarity Medical Systems, Pleasanton, CA) were then obtained, and these were independently read by 2 ROP experts using a web-based system for an image-based diagnosis. Main Outcome Measures: Sensitivity and specificity of image-based diagnosis from the ROP experts were calculated using the clinical diagnosis as the reference standard. Results: Of 1220 examinations, 28 (2%) had a clinical diagnosis of stage 4 or worse. Sensitivity and specificity for stage 4 or worse disease were 75% and 99% for expert 1, and 86% and 99% for expert 2. Sensitivity and specificity for the detection of stage 5 disease were 69% and 99% for both experts. Conclusions: There are inconsistencies in the accuracy of image-based diagnosis of stage 4 and stage 5 ROP when compared with the clinical diagnosis.",

author = "Patel, {Samir N.} and Ranjodh Singh and Jonas, {Karyn E.} and Susan Ostmo and Gupta, {Mrinali P.} and Campbell, {J. Peter} and Michael Chiang and Chan, {R. V.Paul} and Chiang, {Michael F.} and Susan Ostmo and Kemal Sonmez and Campbell, {J. Peter} and Chan, {R. V.Paul} and Karyn Jonas and Jason Horowitz and Osode Coki and Eccles, {Cheryl Ann} and Leora Sarna and Anton Orlin and Audina Berrocal and Catherin Negron and Kimberly Drenser and Kristi Cumming and Tammy Osentoski and Tammy Check and Mary Zajechowski and Thomas Lee and Evan Kruger and Kathryn McGovern and Charles Simmons and Raghu Murthy and Sharon Galvis and Jerome Rotter and Ida Chen and Xiaohui Li and Kent Taylor and Kaye Roll and Jayashree Kalpathy-Cramer and Deniz Erdogmus and Stratis Ioannidis and Martinez-Castellanos, {Maria Ana} and Samantha Salinas-Longoria and Rafael Romero and Andrea Arriola and Francisco Olguin-Manriquez and Miroslava Meraz-Gutierrez and Dulanto-Reinoso, {Carlos M.} and Cristina Montero-Mendoza",

note = "Publisher Copyright: {\textcopyright} 2017 American Academy of Ophthalmology",

year = "2018",

doi = "10.1016/j.oret.2017.04.001",

language = "English (US)",

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pages = "59--64",

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T1 - Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity

AU - Patel, Samir N.

AU - Singh, Ranjodh

AU - Jonas, Karyn E.

AU - Ostmo, Susan

AU - Gupta, Mrinali P.

AU - Campbell, J. Peter

AU - Chiang, Michael

AU - Chan, R. V.Paul

AU - Chiang, Michael F.

AU - Ostmo, Susan

AU - Sonmez, Kemal

AU - Campbell, J. Peter

AU - Chan, R. V.Paul

AU - Jonas, Karyn

AU - Horowitz, Jason

AU - Coki, Osode

AU - Eccles, Cheryl Ann

AU - Sarna, Leora

AU - Orlin, Anton

AU - Berrocal, Audina

AU - Negron, Catherin

AU - Drenser, Kimberly

AU - Cumming, Kristi

AU - Osentoski, Tammy

AU - Check, Tammy

AU - Zajechowski, Mary

AU - Lee, Thomas

AU - Kruger, Evan

AU - McGovern, Kathryn

AU - Simmons, Charles

AU - Murthy, Raghu

AU - Galvis, Sharon

AU - Rotter, Jerome

AU - Chen, Ida

AU - Li, Xiaohui

AU - Taylor, Kent

AU - Roll, Kaye

AU - Kalpathy-Cramer, Jayashree

AU - Erdogmus, Deniz

AU - Ioannidis, Stratis

AU - Martinez-Castellanos, Maria Ana

AU - Salinas-Longoria, Samantha

AU - Romero, Rafael

AU - Arriola, Andrea

AU - Olguin-Manriquez, Francisco

AU - Meraz-Gutierrez, Miroslava

AU - Dulanto-Reinoso, Carlos M.

AU - Montero-Mendoza, Cristina

PY - 2018

Y1 - 2018

N2 - Purpose: To determine the accuracy of image-based diagnosis for stage 4 or worse retinopathy of prematurity (ROP) disease. Design: Prospective cohort study. Participants: We prospectively obtained data, from 8 major ROP centers, for 1220 eye examinations from 230 infants. Methods: An ophthalmologist at each center provided a clinical diagnosis using indirect ophthalmoscopy. Wide-angle retinal images (RetCam; Clarity Medical Systems, Pleasanton, CA) were then obtained, and these were independently read by 2 ROP experts using a web-based system for an image-based diagnosis. Main Outcome Measures: Sensitivity and specificity of image-based diagnosis from the ROP experts were calculated using the clinical diagnosis as the reference standard. Results: Of 1220 examinations, 28 (2%) had a clinical diagnosis of stage 4 or worse. Sensitivity and specificity for stage 4 or worse disease were 75% and 99% for expert 1, and 86% and 99% for expert 2. Sensitivity and specificity for the detection of stage 5 disease were 69% and 99% for both experts. Conclusions: There are inconsistencies in the accuracy of image-based diagnosis of stage 4 and stage 5 ROP when compared with the clinical diagnosis.

AB - Purpose: To determine the accuracy of image-based diagnosis for stage 4 or worse retinopathy of prematurity (ROP) disease. Design: Prospective cohort study. Participants: We prospectively obtained data, from 8 major ROP centers, for 1220 eye examinations from 230 infants. Methods: An ophthalmologist at each center provided a clinical diagnosis using indirect ophthalmoscopy. Wide-angle retinal images (RetCam; Clarity Medical Systems, Pleasanton, CA) were then obtained, and these were independently read by 2 ROP experts using a web-based system for an image-based diagnosis. Main Outcome Measures: Sensitivity and specificity of image-based diagnosis from the ROP experts were calculated using the clinical diagnosis as the reference standard. Results: Of 1220 examinations, 28 (2%) had a clinical diagnosis of stage 4 or worse. Sensitivity and specificity for stage 4 or worse disease were 75% and 99% for expert 1, and 86% and 99% for expert 2. Sensitivity and specificity for the detection of stage 5 disease were 69% and 99% for both experts. Conclusions: There are inconsistencies in the accuracy of image-based diagnosis of stage 4 and stage 5 ROP when compared with the clinical diagnosis.

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Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity

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