Teebi hypertelorism syndrome: Report of a family with previously unrecognized findings

Anne Chun Hui Tsai, Jacqualyn R. Robertson, Ahmad S. Teebi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We present a family consisting of a mother, a daughter, and a son with Teebi hypertelorism syndrome, including some previously unrecognized manifestations. The clinical findings include a prominent forehead, arched eyebrows, pronounced hypertelorism, long philtrum, mild interdigital webbing, fifth-finger clinodactyly, umbilical anomalies, and hypotonia. The mother and daughter also had ptosis requiring surgical correction. The daughter has bilateral iridochorioretinal colobomas with high hyperopia and a small umbilical hernia. The son has less striking facial features but was born with a small omphalocele, large ASD secundum, PDA, bilateral cryptorchidism right hydronephrosis, and a cystic left kidney. The mother had an umbilical hernia requiring surgical correction as a child and a history of heart murmur. Both children have normal hearing and mild developmental delay. Their high-resolution karyotypes were normal and the FISH for 22q11 microdeletion was negative in the daughter. We conclude that cardiac defects in Teebi hypertelorism syndrome are not rare findings and that eye colobomas and renal anomalies were previously unrecognized.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume113
Issue number3
DOIs
StatePublished - Dec 1 2002

Keywords

  • Coloboma
  • Cystic kidney
  • Hydronephrosis
  • Umbilical hernia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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