Technique for construction of an in vivo model of simulated pulmonary metastases

Matthew S. Johnson, Fergus V. Coakley, Timothy J. Carmody, R. Gerald Dreesen, Meryn D. Cohen

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

RATIONALE AND OBJECTIVES. Existing methods used to simulate pulmonary metastases are unsatisfactory. The aim of this study was to create a simple in vivo model of pulmonary metastases by endobronchial deployment of small high-density beads in anesthetized dogs. METHODS. Commercially available decorative beads measuring 2 and 4 mm in diameter and of high density (600 to 1200 Hounsfield units) were deployed in the peripheral airways of anesthetized dogs using catheter and guide wire manipulations through an endotracheal tube. RESULTS. A total of 65 beads were placed in five dogs. Computed tomography demonstrated that 41 (63%) were satisfactorily located in the lung periphery, 9 (14%) were unsatisfactorily located in large airways, and 15 (23%) were not visible. CONCLUSIONS. The endobronchial deployment of small high-density beads in the peripheral airways of anesthetized dogs is a novel and effective technique for creation of an in vivo model of pulmonary metastases.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalInvestigative Radiology
Volume34
Issue number5
DOIs
StatePublished - May 1 1999

Keywords

  • Animal models disease
  • Computed tomography
  • Pulmonary metastases
  • Pulmonary nodules

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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