Abstract
RATIONALE AND OBJECTIVES. Existing methods used to simulate pulmonary metastases are unsatisfactory. The aim of this study was to create a simple in vivo model of pulmonary metastases by endobronchial deployment of small high-density beads in anesthetized dogs. METHODS. Commercially available decorative beads measuring 2 and 4 mm in diameter and of high density (600 to 1200 Hounsfield units) were deployed in the peripheral airways of anesthetized dogs using catheter and guide wire manipulations through an endotracheal tube. RESULTS. A total of 65 beads were placed in five dogs. Computed tomography demonstrated that 41 (63%) were satisfactorily located in the lung periphery, 9 (14%) were unsatisfactorily located in large airways, and 15 (23%) were not visible. CONCLUSIONS. The endobronchial deployment of small high-density beads in the peripheral airways of anesthetized dogs is a novel and effective technique for creation of an in vivo model of pulmonary metastases.
Original language | English (US) |
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Pages (from-to) | 336-340 |
Number of pages | 5 |
Journal | Investigative Radiology |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - May 1999 |
Externally published | Yes |
Keywords
- Animal models disease
- Computed tomography
- Pulmonary metastases
- Pulmonary nodules
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging