TY - JOUR
T1 - Technical factors that influence the determination of microbubble transit rate during contrast echocardiography
AU - Jayaweera, Ananda R.
AU - Skyba, Danny M.
AU - Kaul, Sanjiv
N1 - Funding Information:
For instance, we have shown previously that the microbubble concentration versus videointensity relationship of the two-dinaensional echocardiographic (2DE) system can influence the shape of the time-intensity curves7; however, the effect of this relationship on the time-intensity curves with different From the Cardiovascular Division, University of Virginia School of Medicine, Supported in part by a grant-in-aid from the Virginia Affiliate of the American Heart Association, Glenn Allen, Virginia, and grants from the National Institutes of Health, Bethesda,M aryland (R01-HL48890), and Molecular Biosystems, Inc., San Diego, California, and equipment grants from GeneralE lectricM edical Systems, Milwaukee, Wisconsin, and Hewlert Packard Corp,, Andover, Mass. aEstablished Investigator of the National Center of the American Heart Association, Dallas, Texas. Reprint requests: Ananda R. Jayaweera, PhD, CardiovascularD i-vision, Box 158, Medical Center, University of Virginia, Charlottesville, VA 22908. Copyright 9 1995 by the American Societyo f Echocardiography. 0894-7317/95 $3.00 + 0 27/1/59030
PY - 1995
Y1 - 1995
N2 - The calculation of mean microbubble transit rate (MMTR) during contrast echocardiography provides information regarding the flow through and blood volume of a vascular system. Several technical factors can impact on the accuracy of MMTR determination. In this study, with computer simulation and in vitro and in vivo data, we systematically examined four such factors: the relationship between microbubble concentration versus videointensity, the size of the region of interest and the sampling rate used to derive time-intensity plots, and the method of deriving MMTR (direct numeric calculation vs use of a mathematic model). The results indicate that the effect of these technical factors on the estimation of MMTR can be significant.
AB - The calculation of mean microbubble transit rate (MMTR) during contrast echocardiography provides information regarding the flow through and blood volume of a vascular system. Several technical factors can impact on the accuracy of MMTR determination. In this study, with computer simulation and in vitro and in vivo data, we systematically examined four such factors: the relationship between microbubble concentration versus videointensity, the size of the region of interest and the sampling rate used to derive time-intensity plots, and the method of deriving MMTR (direct numeric calculation vs use of a mathematic model). The results indicate that the effect of these technical factors on the estimation of MMTR can be significant.
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U2 - 10.1016/S0894-7317(05)80408-0
DO - 10.1016/S0894-7317(05)80408-0
M3 - Article
C2 - 7756004
AN - SCOPUS:0029266011
SN - 0894-7317
VL - 8
SP - 198
EP - 206
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 2
ER -