Targeting the bone marrow microenvironment in multiple myeloma

Yawara Kawano, Michele Moschetta, Salomon Manier, Siobhan Glavey, Güllü T. Görgün, Aldo M. Roccaro, Kenneth C. Anderson, Irene M. Ghobrial

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Summary: Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal malignancy. This is mainly due to the supportive role of the BM microenvironment in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM microenvironment is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a non-cellular compartment. In this review, we discuss the interaction between the malignant plasma cell and the BM microenvironment and the strategy to target them.

Original languageEnglish (US)
Pages (from-to)160-172
Number of pages13
JournalImmunological reviews
Volume263
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • BMSCs
  • Bone marrow
  • Immune cells
  • Myeloma
  • Vessel formation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Kawano, Y., Moschetta, M., Manier, S., Glavey, S., Görgün, G. T., Roccaro, A. M., Anderson, K. C., & Ghobrial, I. M. (2015). Targeting the bone marrow microenvironment in multiple myeloma. Immunological reviews, 263(1), 160-172. https://doi.org/10.1111/imr.12233