Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

Erin V. McConnell, Igor Bruzual, Sovitj Pou, Rolf Winter, Rozalia A. Dodean, Martin J. Smilkstein, Alina Krollenbrock, Aaron Nilsen, Lev N. Zakharov, Michael K. Riscoe, J. Stone Doggett

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Medicine & Life Sciences