Targeted signal transduction therapies in myeloid malignancies

Emma Scott, Elizabeth Hexner, Alexander Perl, Martin Carroll

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The myeloid malignancies include the myeloproliferative neoplasms (MPN) including chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). A growing body of evidence documents that these diseases are caused by genetic mutations that constitutively activate tyrosine kinases. They include the BCR/ABL in CML, the V617F JAK2 in Philadelphia chromosome-negative MPN, and the Flt3 ITD and TKD mutations in AML. Trials of the ABL kinase inhibitor, imatinib, have revolutionized the treatment of CML, and there are ongoing studies with other kinase inhibitors in MPN and AML. Here we review results of recent studies with first-generation JAK2 inhibitors in the treatment of MPN and second-generation ABL and Flt3 inhibitors in CML and AML, respectively. It is becoming apparent that although these kinase mutations have similar effects in vitro, each of the diseases has unique features that alter the use of kinase inhibitors in the clinic.

Original languageEnglish (US)
Pages (from-to)358-365
Number of pages8
JournalCurrent oncology reports
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Signal Transduction
Phosphotransferases
Mutation
Neoplasms
Philadelphia Chromosome
Inborn Genetic Diseases
Second Primary Neoplasms
Therapeutics
Protein-Tyrosine Kinases

Keywords

  • Acute myeloid leukemia
  • BCR/ABL
  • Chronic myeloid leukemia
  • Imatinib
  • JAK2
  • Myeloproliferative neoplasms
  • Nilotinib
  • Signal transduction

ASJC Scopus subject areas

  • Oncology

Cite this

Targeted signal transduction therapies in myeloid malignancies. / Scott, Emma; Hexner, Elizabeth; Perl, Alexander; Carroll, Martin.

In: Current oncology reports, Vol. 12, No. 6, 01.11.2010, p. 358-365.

Research output: Contribution to journalReview article

Scott, Emma ; Hexner, Elizabeth ; Perl, Alexander ; Carroll, Martin. / Targeted signal transduction therapies in myeloid malignancies. In: Current oncology reports. 2010 ; Vol. 12, No. 6. pp. 358-365.
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