Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin

Samuel J. Hobbs, Jeffrey C. Nolz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Tissue-resident memory (TRM) T cells provide a first line of host defense against pathogen invasion at environmental barrier tissues. Here, Hobbs and Nolz describe a mechanism to rapidly expand the number of antigen-specific TRM CD8+ T cells in the skin, using topical application of antigenic peptide to boost localized protective immunity.

Original languageEnglish (US)
Pages (from-to)2990-2997.e2
JournalCell Reports
Volume29
Issue number10
DOIs
StatePublished - Dec 3 2019

Keywords

  • CD8+ T cells
  • memory T cells
  • tissue-resident T cells
  • viral infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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