@article{887e935bd10c416eaf921594256066da,
title = "Targeted disruption of the melanocortin-4 receptor results in obesity in mice",
abstract = "The melanocortin-4 receptor (MC4-R) is a G protein-coupled, seven- transmembrane receptor expressed in the brain. Inactivation of this receptor by gene targeting results in mice that develop a maturity onset obesity syndrome associated with hyperphagia, hyperinsulinemia, and hyperglycemia. This syndrome recapitulates several of the characteristic features of the agouti obesity syndrome, which results from ectopic expression of agouti protein, a pigmentation factor normally expressed in the skin. Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R.",
author = "Dennis Huszar and Lynch, {Catherine A.} and Victoria Fairchild-Huntress and Dunmore, {Judy H.} and Qing Fang and Berkemeier, {Lucy R.} and Wei Gu and Kesterson, {Robert A.} and Boston, {Bruce A.} and Cone, {Roger D.} and Smith, {Francoise J.} and Campfield, {L. Arthur} and Paul Burn and Lee Frank",
note = "Funding Information: Correspondence should be addressed to D. H. The authors would like to thank Bob Tepper and Lou Tartaglia for helpful advice, Paul Paglierani and Steve Ellis for sequencing support, Robert Wurzberger and Renata Tenenbaum for assistance with the leptin and insulin assays, Reginald Riley and Heather MacEachern for animal care, and Lisa DiRocco for genotyping. We would also like to acknowledge the support and helpful discussions from our colleagues at Millennium, Hoffmann-LaRoche, and the Vollum Institute. This work was financially supported by Hoffmann–La Roche, Inc.",
year = "1997",
month = jan,
day = "10",
doi = "10.1016/S0092-8674(00)81865-6",
language = "English (US)",
volume = "88",
pages = "131--141",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}