Targeted complexes of lanthanide(III) ions as therapeutic and diagnostic pharmaceuticals

Mark Woods, Zoltan Kovacs, A. Dean Sherry

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The physical, magnetic and nuclear properties of the lanthanide ions have rendered them ideal for use in both diagnostic and therapeutic pharmaceuticals. Recent innovations in biotechnology have opened new possibilities for the design of such pharmaceuticals. By conjugating a suitable targeting vector to the metal chelate it may be possible to target tissue type, cell type, individual proteins and even specific nucleic acid sequences. This review describes recent advances in the targeting of these complexes and discusses their potential in the development of new inorganic pharmaceuticals.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalJournal of Supramolecular Chemistry
Volume2
Issue number1-3
DOIs
StatePublished - Jan 2002
Externally publishedYes

Fingerprint

Lanthanoid Series Elements
Rare earth elements
Drug products
Ions
Nuclear properties
Nucleic acid sequences
Pharmaceutical Preparations
Biotechnology
Magnetic properties
Physical properties
Innovation
Metals
Tissue
Proteins

Keywords

  • Bifunctional chelators
  • Lanthanides
  • MRI contrast agents
  • Radiopharmaceuticals

ASJC Scopus subject areas

  • Chemistry(all)
  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry

Cite this

Targeted complexes of lanthanide(III) ions as therapeutic and diagnostic pharmaceuticals. / Woods, Mark; Kovacs, Zoltan; Sherry, A. Dean.

In: Journal of Supramolecular Chemistry, Vol. 2, No. 1-3, 01.2002, p. 1-15.

Research output: Contribution to journalArticle

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