Tamoxifen in the treatment and chemoprevention of breast cancer.

V. A. Boothe, R. F. Pommier, J. T. Vetto

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Synthesized in 1966 and initially tested as a potential contraceptive, the nonsteroidal antiestrogen tamoxifen was subsequently found to have therapeutic benefits in the therapy of breast cancer. Today, tamoxifen is widely used in the treatment of this disease both in an adjuvant setting and for metastatic tumor. This article explores the history, pharmacology, and adverse effects of tamoxifen and summarizes the clinical evidence for its current indications and potential future use as a chemopreventative agent.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalCancer practice
Volume2
Issue number5
StatePublished - Sep 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)
  • Oncology

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