Tamoxifen in the treatment and chemoprevention of breast cancer.

V. A. Boothe, R. F. Pommier, J. T. Vetto

    Research output: Contribution to journalReview articlepeer-review

    3 Scopus citations


    Synthesized in 1966 and initially tested as a potential contraceptive, the nonsteroidal antiestrogen tamoxifen was subsequently found to have therapeutic benefits in the therapy of breast cancer. Today, tamoxifen is widely used in the treatment of this disease both in an adjuvant setting and for metastatic tumor. This article explores the history, pharmacology, and adverse effects of tamoxifen and summarizes the clinical evidence for its current indications and potential future use as a chemopreventative agent.

    Original languageEnglish (US)
    Pages (from-to)335-342
    Number of pages8
    JournalCancer practice
    Issue number5
    StatePublished - Sep 1 1994

    ASJC Scopus subject areas

    • Nursing(all)
    • Oncology

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