Tactics for the isolation of interleukin-2-induced immediate-early genes

Carol Beadling, Kendall A. Smith

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    Interleukin-2 (IL-2), a 15 kDa protein secreted by antigen-activated T lymphocytes, plays a central role in the generation of an immune response. Initially characterized as a T cell growth factor, IL-2 has subsequently been found to act on all lymphoid cell types, inducing both their proliferation and functional differentiation. The effects of IL-2 are mediated by the activation of a specific cell-surface receptor (IL-2R), which is comprised of at least three distinct proteins. Early biochemical signaling events triggered upon IL-2R activation have recently begun to be elucidated, and a number of genes have been identified which are specifically induced by IL-2. The task now at hand is to link the biochemical signaling pathways activated by IL-2 with the regulation of gene expression, and to delineate the roles of these gene products in IL-2-mediated proliferation and differentiation.

    Original languageEnglish (US)
    Pages (from-to)365-373
    Number of pages9
    JournalSeminars in Immunology
    Volume5
    Issue number5
    DOIs
    StatePublished - Oct 1993

    Keywords

    • Interleukin-2-induced genes

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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