Tactics for the isolation of interleukin-2-induced immediate-early genes

Carol Beadling, Kendall A. Smith

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Interleukin-2 (IL-2), a 15 kDa protein secreted by antigen-activated T lymphocytes, plays a central role in the generation of an immune response. Initially characterized as a T cell growth factor, IL-2 has subsequently been found to act on all lymphoid cell types, inducing both their proliferation and functional differentiation. The effects of IL-2 are mediated by the activation of a specific cell-surface receptor (IL-2R), which is comprised of at least three distinct proteins. Early biochemical signaling events triggered upon IL-2R activation have recently begun to be elucidated, and a number of genes have been identified which are specifically induced by IL-2. The task now at hand is to link the biochemical signaling pathways activated by IL-2 with the regulation of gene expression, and to delineate the roles of these gene products in IL-2-mediated proliferation and differentiation.

Original languageEnglish (US)
Pages (from-to)365-373
Number of pages9
JournalSeminars in Immunology
Volume5
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Immediate-Early Genes
Interleukin-2
Gene Expression Regulation
Cell Surface Receptors
Genes
Proteins
Hand
Lymphocytes
T-Lymphocytes
Antigens

Keywords

  • Interleukin-2-induced genes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Tactics for the isolation of interleukin-2-induced immediate-early genes. / Beadling, Carol; Smith, Kendall A.

In: Seminars in Immunology, Vol. 5, No. 5, 1993, p. 365-373.

Research output: Contribution to journalArticle

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