Abstract
Interleukin-2 (IL-2), a 15 kDa protein secreted by antigen-activated T lymphocytes, plays a central role in the generation of an immune response. Initially characterized as a T cell growth factor, IL-2 has subsequently been found to act on all lymphoid cell types, inducing both their proliferation and functional differentiation. The effects of IL-2 are mediated by the activation of a specific cell-surface receptor (IL-2R), which is comprised of at least three distinct proteins. Early biochemical signaling events triggered upon IL-2R activation have recently begun to be elucidated, and a number of genes have been identified which are specifically induced by IL-2. The task now at hand is to link the biochemical signaling pathways activated by IL-2 with the regulation of gene expression, and to delineate the roles of these gene products in IL-2-mediated proliferation and differentiation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 365-373 |
| Number of pages | 9 |
| Journal | Seminars in Immunology |
| Volume | 5 |
| Issue number | 5 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- Interleukin-2-induced genes
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Infectious Diseases
Cite this
Tactics for the isolation of interleukin-2-induced immediate-early genes. / Beadling, Carol; Smith, Kendall A.
In: Seminars in Immunology, Vol. 5, No. 5, 1993, p. 365-373.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tactics for the isolation of interleukin-2-induced immediate-early genes
AU - Beadling, Carol
AU - Smith, Kendall A.
PY - 1993
Y1 - 1993
N2 - Interleukin-2 (IL-2), a 15 kDa protein secreted by antigen-activated T lymphocytes, plays a central role in the generation of an immune response. Initially characterized as a T cell growth factor, IL-2 has subsequently been found to act on all lymphoid cell types, inducing both their proliferation and functional differentiation. The effects of IL-2 are mediated by the activation of a specific cell-surface receptor (IL-2R), which is comprised of at least three distinct proteins. Early biochemical signaling events triggered upon IL-2R activation have recently begun to be elucidated, and a number of genes have been identified which are specifically induced by IL-2. The task now at hand is to link the biochemical signaling pathways activated by IL-2 with the regulation of gene expression, and to delineate the roles of these gene products in IL-2-mediated proliferation and differentiation.
AB - Interleukin-2 (IL-2), a 15 kDa protein secreted by antigen-activated T lymphocytes, plays a central role in the generation of an immune response. Initially characterized as a T cell growth factor, IL-2 has subsequently been found to act on all lymphoid cell types, inducing both their proliferation and functional differentiation. The effects of IL-2 are mediated by the activation of a specific cell-surface receptor (IL-2R), which is comprised of at least three distinct proteins. Early biochemical signaling events triggered upon IL-2R activation have recently begun to be elucidated, and a number of genes have been identified which are specifically induced by IL-2. The task now at hand is to link the biochemical signaling pathways activated by IL-2 with the regulation of gene expression, and to delineate the roles of these gene products in IL-2-mediated proliferation and differentiation.
KW - Interleukin-2-induced genes
UR - http://www.scopus.com/inward/record.url?scp=0027674442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027674442&partnerID=8YFLogxK
M3 - Article
C2 - 8260652
AN - SCOPUS:0027674442
VL - 5
SP - 365
EP - 373
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
IS - 5
ER -