T69D/N pol mutation, human immunodeficiency virus type 1 RNA levels, and syncytium-inducing phenotype are associated with CD4 cell depletion during didanosine therapy

Willscott E. Naugler, Florence H. Yong, Vincent J. Carey, Joan A. Dragavon, Robert W. Coombs, Lisa M. Frenkel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The contribution of virologic and host factors to CD4 cell depletion associated with human immunodeficiency virus (HIV) type 1 was evaluated in children drawn from a larger efficacy trial of 2 doses of didanosine (ddI) monotherapy (Pediatric AIDS Clinical Trials Group 144). Thirty children, half with stable CD4 cell counts (nonprogressors) and half with a marked decline in CD4 cells (progressors), were studied during 60-72 weeks of ddI therapy. The children were matched for age and CD4 cell counts at study entry. Three viral parameters, syncytium-inducing phenotype, higher virus load, and mutation in HIV-1 pol encoding the T69D/N mutation, were associated with disease progression. Disease progression was not associated with mutations in the reverse-transcriptase gene previously associated with resistance to ddI (L74V, K65R, or M184V). The selection of the T69D/N mutation in children with HIV-1 disease progression during ddI therapy suggests that this mutation confers a fitness advantage to the virus that may include resistance to ddI.

Original languageEnglish (US)
Pages (from-to)448-455
Number of pages8
JournalJournal of Infectious Diseases
Volume185
Issue number4
DOIs
StatePublished - Feb 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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