T-cell receptor peptide therapy in EAE and MS

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Synthetic peptides corresponding to germline TCR Vβ8.2 sequences overexpressed by Lewis rat encephalitogenic T cells are effective in the prevention and treatment of autoimmune encephalomyelitis (EAE). In evaluating optimal conditions for identifying disease-relevant target Vβ genes, we found that the biased expression of Vβ8.2 was most pronounced in the CNS among activated, IL-2 responsive T cells, but was weakly reflected in the cerebrospinal fluid. Evaluation of basic protein reactive T cells from patients with multiple sclerosis revealed biased expression of Vβ5.2 and to a lesser degree, Vβ6.1. Treatment of 11 MS patients with synthetic TCR Vβ5.2 and Vβ6.1 CDR2 peptides boosted the frequency of anti-TCR reactive T cells in a majority of patients, without compromising recall immunity or causing side effects. TCR peptides may be useful in the treatment of human autoimmune diseases, providing that disease-relevant V genes can be identified.

Original languageEnglish (US)
Pages (from-to)S51-S53
JournalClinical and experimental rheumatology
Volume11
Issue numberSUPPL. 8
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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