T-cell receptor affinity in thymic development

Amy E. Moran, Kristin A. Hogquist

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Understanding the thymic processes that support the generation of functionally competent and self-tolerant lymphocytes requires dissection of the T-cell receptor (TCR) response to ligands of different affinities. In spatially segregated regions of the thymus, with unique expression of proteases and cytokines, TCR affinity guides a number of cell fate decisions. Yet affinity alone does not explain the selection paradox. Increasing evidence suggests that the 'altered peptide' model of the 1980s together with the affinity model might best explain how the thymus supports conventional and regulatory T-cell development. Development of new tools to study the strength of TCR signals perceived by T cells, novel regulatory T-cell transgenic mice, and tetramer enrichment strategies have provided an insight into the nature of TCR signals perceived during thymocyte development. These topics are discussed and support for the prevailing hypotheses is presented.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalImmunology
Volume135
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Affinity
  • Natural killer T cell
  • Regulatory T cell
  • T-cell receptor
  • Thymus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'T-cell receptor affinity in thymic development'. Together they form a unique fingerprint.

  • Cite this