T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats

Halina Offner, G. A. Hashim, B. Celnik, A. Galang, X. Li, F. R. Burns, N. Shen, E. Heber-Katz, Arthur Vandenbark

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The major encephalitogenic epitope for Lewis rats is the 72-89 sequence of guinea pig basic protein (GP-BP) or rat basic protein (Rt-BP). T cells responsive to this epitope are I-A-restricted and preferentially express the Vα2:Vβ8 gene combination in their TCR. In this work, we describe for the first time the delayed appearance of T cells specific for additional discrete determinant of BP, the nonencephalitogenic 55-68 sequence of GP-BP restricted by I-A, and the encephalitogenic 87-99 sequence of Rt-BP restricted by I-E. The TCR Vα2:Vβ8 gene combination was expressed by both encephalitogenic GP-BP S72-89 and Rt-BP S87-99 T cell specificities but not by GP-BP 44-68-specific T cells. This is the first demonstration of I-E-restricted encephalitogenic T cells in Lewis rats and supports the conclusion that the I-E class II locus is involved in autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)355-367
Number of pages13
JournalJournal of Experimental Medicine
Volume170
Issue number2
StatePublished - 1989
Externally publishedYes

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Myelin Basic Protein
Epitopes
T-Lymphocytes
Guinea Pigs
Proteins
T-Cell Antigen Receptor Specificity
Genes
Autoimmune Diseases

ASJC Scopus subject areas

  • Immunology

Cite this

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. / Offner, Halina; Hashim, G. A.; Celnik, B.; Galang, A.; Li, X.; Burns, F. R.; Shen, N.; Heber-Katz, E.; Vandenbark, Arthur.

In: Journal of Experimental Medicine, Vol. 170, No. 2, 1989, p. 355-367.

Research output: Contribution to journalArticle

Offner, H, Hashim, GA, Celnik, B, Galang, A, Li, X, Burns, FR, Shen, N, Heber-Katz, E & Vandenbark, A 1989, 'T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats', Journal of Experimental Medicine, vol. 170, no. 2, pp. 355-367.
Offner, Halina ; Hashim, G. A. ; Celnik, B. ; Galang, A. ; Li, X. ; Burns, F. R. ; Shen, N. ; Heber-Katz, E. ; Vandenbark, Arthur. / T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. In: Journal of Experimental Medicine. 1989 ; Vol. 170, No. 2. pp. 355-367.
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AU - Offner, Halina

AU - Hashim, G. A.

AU - Celnik, B.

AU - Galang, A.

AU - Li, X.

AU - Burns, F. R.

AU - Shen, N.

AU - Heber-Katz, E.

AU - Vandenbark, Arthur

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