T cell co-stimulatory molecules: A co-conspirator in the pathogenesis of eosinophilic esophagitis?

Zili Zhang, Thomas J. Sferra, Yasemen Eroglu

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.

Original languageEnglish (US)
Pages (from-to)1497-1506
Number of pages10
JournalDigestive diseases and sciences
Volume58
Issue number6
DOIs
StatePublished - Jun 1 2013

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Keywords

  • Co-stimulatory molecules
  • Eosinophilic esophagitis
  • HVEM
  • Light
  • OX40
  • Th2 cells

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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