T cell co-stimulatory molecules

A co-conspirator in the pathogenesis of eosinophilic esophagitis?

Zili Zhang, Thomas J. Sferra, Yasemen Eroglu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.

Original languageEnglish (US)
Pages (from-to)1497-1506
Number of pages10
JournalDigestive Diseases and Sciences
Volume58
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Eosinophilic Esophagitis
T-Lymphocytes
Th2 Cells
Food Hypersensitivity
Gastrointestinal Diseases
Atopic Dermatitis
Eosinophils
Esophagus
Ligation
Asthma
Inflammation
Light
Therapeutics

Keywords

  • Co-stimulatory molecules
  • Eosinophilic esophagitis
  • HVEM
  • Light
  • OX40
  • Th2 cells

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

T cell co-stimulatory molecules : A co-conspirator in the pathogenesis of eosinophilic esophagitis? / Zhang, Zili; Sferra, Thomas J.; Eroglu, Yasemen.

In: Digestive Diseases and Sciences, Vol. 58, No. 6, 06.2013, p. 1497-1506.

Research output: Contribution to journalArticle

@article{2fa687d5a0bd4b41be61e4cc29fb26ad,
title = "T cell co-stimulatory molecules: A co-conspirator in the pathogenesis of eosinophilic esophagitis?",
abstract = "Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.",
keywords = "Co-stimulatory molecules, Eosinophilic esophagitis, HVEM, Light, OX40, Th2 cells",
author = "Zili Zhang and Sferra, {Thomas J.} and Yasemen Eroglu",
year = "2013",
month = "6",
doi = "10.1007/s10620-013-2599-8",
language = "English (US)",
volume = "58",
pages = "1497--1506",
journal = "American Journal of Digestive Diseases and Nutrition",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "6",

}

TY - JOUR

T1 - T cell co-stimulatory molecules

T2 - A co-conspirator in the pathogenesis of eosinophilic esophagitis?

AU - Zhang, Zili

AU - Sferra, Thomas J.

AU - Eroglu, Yasemen

PY - 2013/6

Y1 - 2013/6

N2 - Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.

AB - Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.

KW - Co-stimulatory molecules

KW - Eosinophilic esophagitis

KW - HVEM

KW - Light

KW - OX40

KW - Th2 cells

UR - http://www.scopus.com/inward/record.url?scp=84879500382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879500382&partnerID=8YFLogxK

U2 - 10.1007/s10620-013-2599-8

DO - 10.1007/s10620-013-2599-8

M3 - Article

VL - 58

SP - 1497

EP - 1506

JO - American Journal of Digestive Diseases and Nutrition

JF - American Journal of Digestive Diseases and Nutrition

SN - 0163-2116

IS - 6

ER -