Abstract
Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1497-1506 |
| Number of pages | 10 |
| Journal | Digestive Diseases and Sciences |
| Volume | 58 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2013 |
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Keywords
- Co-stimulatory molecules
- Eosinophilic esophagitis
- HVEM
- Light
- OX40
- Th2 cells
ASJC Scopus subject areas
- Gastroenterology
- Physiology
Cite this
T cell co-stimulatory molecules : A co-conspirator in the pathogenesis of eosinophilic esophagitis? / Zhang, Zili; Sferra, Thomas J.; Eroglu, Yasemen.
In: Digestive Diseases and Sciences, Vol. 58, No. 6, 06.2013, p. 1497-1506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cell co-stimulatory molecules
T2 - A co-conspirator in the pathogenesis of eosinophilic esophagitis?
AU - Zhang, Zili
AU - Sferra, Thomas J.
AU - Eroglu, Yasemen
PY - 2013/6
Y1 - 2013/6
N2 - Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.
AB - Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.
KW - Co-stimulatory molecules
KW - Eosinophilic esophagitis
KW - HVEM
KW - Light
KW - OX40
KW - Th2 cells
UR - http://www.scopus.com/inward/record.url?scp=84879500382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879500382&partnerID=8YFLogxK
U2 - 10.1007/s10620-013-2599-8
DO - 10.1007/s10620-013-2599-8
M3 - Article
VL - 58
SP - 1497
EP - 1506
JO - American Journal of Digestive Diseases and Nutrition
JF - American Journal of Digestive Diseases and Nutrition
SN - 0163-2116
IS - 6
ER -