Systems immunogenetics of vaccines

Michael Mooney, Shannon McWeeney, Rafick Pierre Sékaly

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Vaccines are the most cost effective public health measure for preventing viral infection and limiting epidemic spread within susceptible populations. However, the efficacy of current protective vaccines is highly variable, particularly in aging populations. In addition, there have been a number of challenges in the development of new vaccines due to a lack of detailed understanding of the immune correlates of protection. To identify the mechanisms underlying the variability of the immune response to vaccines, system-level tools need to be developed that will further our understanding of virus-host interactions and correlates of vaccine efficacy. This will provide critical information for rational vaccine design and allow the development of an analog to the "precision medicine" framework (already acknowledged as a powerful approach in medicine and therapeutics) to be applied to vaccinology.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalSeminars in Immunology
Volume25
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • Infectious disease
  • Systems biology
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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