TY - JOUR
T1 - Systems biology in cancer research
T2 - genomics to cellomics.
AU - Stilwell, Jackie L.
AU - Guan, Yinghui
AU - Neve, Richard M.
AU - Gray, Joe W.
PY - 2007
Y1 - 2007
N2 - Cancers result from large-scale deregulation of genes that lead to cancer pathophysiologies such as increase proliferation, decreased apoptosis, increased motility, increased angiogenesis, and others. Genes that influence proliferation and apoptosis are particularly attractive as therapeutic targets. To identify genes that influence these phenotypes, we have developed simple and rapid methods to measure apoptosis and cell proliferation using high content screening with YO-PRO-1 and anti-BrdU staining of BrdU pulsed cells, respectively.
AB - Cancers result from large-scale deregulation of genes that lead to cancer pathophysiologies such as increase proliferation, decreased apoptosis, increased motility, increased angiogenesis, and others. Genes that influence proliferation and apoptosis are particularly attractive as therapeutic targets. To identify genes that influence these phenotypes, we have developed simple and rapid methods to measure apoptosis and cell proliferation using high content screening with YO-PRO-1 and anti-BrdU staining of BrdU pulsed cells, respectively.
UR - http://www.scopus.com/inward/record.url?scp=34547873082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547873082&partnerID=8YFLogxK
M3 - Article
C2 - 16988415
AN - SCOPUS:34547873082
SN - 1064-3745
VL - 356
SP - 353
EP - 365
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -