Systems biology in cancer research: genomics to cellomics.

Jackie L. Stilwell, Yinghui Guan, Richard M. Neve, Joe Gray

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cancers result from large-scale deregulation of genes that lead to cancer pathophysiologies such as increase proliferation, decreased apoptosis, increased motility, increased angiogenesis, and others. Genes that influence proliferation and apoptosis are particularly attractive as therapeutic targets. To identify genes that influence these phenotypes, we have developed simple and rapid methods to measure apoptosis and cell proliferation using high content screening with YO-PRO-1 and anti-BrdU staining of BrdU pulsed cells, respectively.

Original languageEnglish (US)
Pages (from-to)353-365
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume356
StatePublished - 2007
Externally publishedYes

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Systems Biology
Genomics
Bromodeoxyuridine
Apoptosis
Research
Genes
Neoplasms
Cell Proliferation
Staining and Labeling
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Systems biology in cancer research : genomics to cellomics. / Stilwell, Jackie L.; Guan, Yinghui; Neve, Richard M.; Gray, Joe.

In: Methods in molecular biology (Clifton, N.J.), Vol. 356, 2007, p. 353-365.

Research output: Contribution to journalArticle

Stilwell, Jackie L. ; Guan, Yinghui ; Neve, Richard M. ; Gray, Joe. / Systems biology in cancer research : genomics to cellomics. In: Methods in molecular biology (Clifton, N.J.). 2007 ; Vol. 356. pp. 353-365.
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