Systems biology in cancer research: genomics to cellomics.

Jackie L. Stilwell, Yinghui Guan, Richard M. Neve, Joe W. Gray

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Cancers result from large-scale deregulation of genes that lead to cancer pathophysiologies such as increase proliferation, decreased apoptosis, increased motility, increased angiogenesis, and others. Genes that influence proliferation and apoptosis are particularly attractive as therapeutic targets. To identify genes that influence these phenotypes, we have developed simple and rapid methods to measure apoptosis and cell proliferation using high content screening with YO-PRO-1 and anti-BrdU staining of BrdU pulsed cells, respectively.

Original languageEnglish (US)
Pages (from-to)353-365
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume356
StatePublished - 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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