Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

P. Rada, Gregory Mark, E. Pothos, B. G. Hoebel

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p <.01) while it increased DA (55%, p <.01). The effects of morphine were eliminated by naloxone. The results comfirm that morphine increases DA and in addition, demonstrate an inhibitory influence of this opiate on extracellular levels of ACh in the NAC.

Original languageEnglish (US)
Pages (from-to)1133-1136
Number of pages4
JournalNeuropharmacology
Volume30
Issue number10
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Nucleus Accumbens
Morphine
Acetylcholine
Dopamine
Opiate Alkaloids
Microdialysis
Naloxone
Injections

Keywords

  • Acetycholine
  • Dopamine
  • Microdialysis
  • Morphine
  • Nucleus Accumbens
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats. / Rada, P.; Mark, Gregory; Pothos, E.; Hoebel, B. G.

In: Neuropharmacology, Vol. 30, No. 10, 1991, p. 1133-1136.

Research output: Contribution to journalArticle

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