Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

P. Rada, G. P. Mark, E. Pothos, B. G. Hoebel

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p < .01) while it increased DA (55%, p < .01). The effects of morphine were eliminated by naloxone. The results comfirm that morphine increases DA and in addition, demonstrate an inhibitory influence of this opiate on extracellular levels of ACh in the NAC.

Original languageEnglish (US)
Pages (from-to)1133-1136
Number of pages4
JournalNeuropharmacology
Volume30
Issue number10
DOIs
StatePublished - Oct 1991

Keywords

  • Acetycholine
  • Dopamine
  • Microdialysis
  • Morphine
  • Nucleus Accumbens
  • Rat

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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