Systemic immune responses after experimental stroke

Halina Offner; Patricia D. Hurn

doi:10.1007/978-1-4614-8915-3_10

Systemic immune responses after experimental stroke

Halina Offner, Patricia D. Hurn

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Stroke-induced pathology involves biphasic induction of an early massive peripheral immune cell activation followed by delayed, progressive splenic apoptosis and consequent immunosuppression. In this chapter, we review key immunological aspects of stroke induction and immunosuppression in the context of an emerging concept called "brain-spleen injury cycling." Moreover, we discuss the contribution to stroke severity of immune cells, including T and B cells, regulatory IL-10 secreting B cells and the programmed death receptor/ligand inhibitory pathway. Finally, we propose two novel therapeutic approaches that may limit stroke pathology and ameliorate downstream immunosuppression.

Original language	English (US)
Title of host publication	Immunological Mechanisms and Therapies in Brain Injuries and Stroke
Publisher	Springer New York
Pages	153-176
Number of pages	24
ISBN (Electronic)	9781461489153
ISBN (Print)	9781461489146
DOIs	https://doi.org/10.1007/978-1-4614-8915-3_10
State	Published - Jan 1 2014

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1007/978-1-4614-8915-3_10

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Y1 - 2014/1/1

N2 - Stroke-induced pathology involves biphasic induction of an early massive peripheral immune cell activation followed by delayed, progressive splenic apoptosis and consequent immunosuppression. In this chapter, we review key immunological aspects of stroke induction and immunosuppression in the context of an emerging concept called "brain-spleen injury cycling." Moreover, we discuss the contribution to stroke severity of immune cells, including T and B cells, regulatory IL-10 secreting B cells and the programmed death receptor/ligand inhibitory pathway. Finally, we propose two novel therapeutic approaches that may limit stroke pathology and ameliorate downstream immunosuppression.

AB - Stroke-induced pathology involves biphasic induction of an early massive peripheral immune cell activation followed by delayed, progressive splenic apoptosis and consequent immunosuppression. In this chapter, we review key immunological aspects of stroke induction and immunosuppression in the context of an emerging concept called "brain-spleen injury cycling." Moreover, we discuss the contribution to stroke severity of immune cells, including T and B cells, regulatory IL-10 secreting B cells and the programmed death receptor/ligand inhibitory pathway. Finally, we propose two novel therapeutic approaches that may limit stroke pathology and ameliorate downstream immunosuppression.

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ER -

Systemic immune responses after experimental stroke

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