Systemic immune responses after experimental stroke

Halina Offner, Patricia D. Hurn

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stroke-induced pathology involves biphasic induction of an early massive peripheral immune cell activation followed by delayed, progressive splenic apoptosis and consequent immunosuppression. In this chapter, we review key immunological aspects of stroke induction and immunosuppression in the context of an emerging concept called "brain-spleen injury cycling." Moreover, we discuss the contribution to stroke severity of immune cells, including T and B cells, regulatory IL-10 secreting B cells and the programmed death receptor/ligand inhibitory pathway. Finally, we propose two novel therapeutic approaches that may limit stroke pathology and ameliorate downstream immunosuppression.

Original languageEnglish (US)
Title of host publicationImmunological Mechanisms and Therapies in Brain Injuries and Stroke
PublisherSpringer New York
Pages153-176
Number of pages24
ISBN (Electronic)9781461489153
ISBN (Print)9781461489146
DOIs
StatePublished - Jan 1 2014

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Stroke
Immunosuppression
B-Lymphocytes
Pathology
Death Domain Receptors
Interleukin-10
Brain Injuries
Cell Death
Spleen
Apoptosis
Ligands
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Offner, H., & Hurn, P. D. (2014). Systemic immune responses after experimental stroke. In Immunological Mechanisms and Therapies in Brain Injuries and Stroke (pp. 153-176). Springer New York. https://doi.org/10.1007/978-1-4614-8915-3_10

Systemic immune responses after experimental stroke. / Offner, Halina; Hurn, Patricia D.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer New York, 2014. p. 153-176.

Research output: Chapter in Book/Report/Conference proceedingChapter

Offner, H & Hurn, PD 2014, Systemic immune responses after experimental stroke. in Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer New York, pp. 153-176. https://doi.org/10.1007/978-1-4614-8915-3_10
Offner H, Hurn PD. Systemic immune responses after experimental stroke. In Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer New York. 2014. p. 153-176 https://doi.org/10.1007/978-1-4614-8915-3_10
Offner, Halina ; Hurn, Patricia D. / Systemic immune responses after experimental stroke. Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer New York, 2014. pp. 153-176
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