Systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood

Nicky Leeborg, Thomas Russell, Guang Fan

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease of childhood is a rare, aggressive T-cell malignancy recently recognized in the 2008 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This disease classically arises in the context of primary acute or chronic active EBV infection, and it is characterized by a clonal proliferation of EBV-infected T cells with an activated cytotoxic phenotype. Most patients have a fulminant clinical course. The clinical and pathologic features of the disease overlap with other conditions, such as infectious mononucleosis, chronic active EBV infection, hemophagocytic lymphohistiocytosis, and natural killer cell malignancies. Here we report a case of systemic EBV+ T-cell lymphoproliferative disease of childhood, and the key features and diagnostic pitfalls of this entity are discussed.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalPathology Case Reviews
Volume17
Issue number3
DOIs
StatePublished - May 1 2012

Keywords

  • Epstein-Barr virus
  • T-cell lymphoproliferative disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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