Systemic effects of TRAIL (TNF-related apoptosis-inducing ligand) during acute γ-irradiation

E. N. Arkhipova, I. B. Alchinova, A. B. Cherepov, D. V. Rozanov, Yu S. Medvedeva, M. Yu Karganov

Research output: Contribution to journalArticle

Abstract

The effects of TRAIL at various physiological levels were studied on 101/Hf and C3H/Sn mice during acute γ-irradiation with 750 R. An intravenous injection of TRAIL attenuated the effects of γ-irradiation on the body weight, subfractions of blood plasma, horizontal and vertical activity in the open-field test, tissue injury in the small intestine and liver, and content of Hassall's corpuscles in the thymus. The degree of these changes differed in mice of study strains.

Original languageEnglish (US)
Pages (from-to)452-456
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume156
Issue number4
DOIs
StatePublished - Jan 1 2014

Keywords

  • TRAIL
  • apoptosis
  • mice
  • radioresistance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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