Systemic Delivery and Biodistribution of Cisplatin in Vivo

Yu Hsuan Chu, Martha Sibrian-Vazquez, Jorge O. Escobedo, Amanda R. Phillips, D. Thomas Dickey, Qi Wang, Martina Ralle, Peter Steyger, Robert M. Strongin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

Original languageEnglish (US)
Pages (from-to)2677-2682
Number of pages6
JournalMolecular Pharmaceutics
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2016

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Cisplatin
Drug Therapy
Pharmaceutical Preparations
Neoplasms

Keywords

  • cisplatin
  • conjugate
  • ototoxicity
  • Texas Red
  • tracer

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

Cite this

Chu, Y. H., Sibrian-Vazquez, M., Escobedo, J. O., Phillips, A. R., Dickey, D. T., Wang, Q., ... Strongin, R. M. (2016). Systemic Delivery and Biodistribution of Cisplatin in Vivo. Molecular Pharmaceutics, 13(8), 2677-2682. https://doi.org/10.1021/acs.molpharmaceut.6b00240

Systemic Delivery and Biodistribution of Cisplatin in Vivo. / Chu, Yu Hsuan; Sibrian-Vazquez, Martha; Escobedo, Jorge O.; Phillips, Amanda R.; Dickey, D. Thomas; Wang, Qi; Ralle, Martina; Steyger, Peter; Strongin, Robert M.

In: Molecular Pharmaceutics, Vol. 13, No. 8, 01.08.2016, p. 2677-2682.

Research output: Contribution to journalArticle

Chu, YH, Sibrian-Vazquez, M, Escobedo, JO, Phillips, AR, Dickey, DT, Wang, Q, Ralle, M, Steyger, P & Strongin, RM 2016, 'Systemic Delivery and Biodistribution of Cisplatin in Vivo', Molecular Pharmaceutics, vol. 13, no. 8, pp. 2677-2682. https://doi.org/10.1021/acs.molpharmaceut.6b00240
Chu YH, Sibrian-Vazquez M, Escobedo JO, Phillips AR, Dickey DT, Wang Q et al. Systemic Delivery and Biodistribution of Cisplatin in Vivo. Molecular Pharmaceutics. 2016 Aug 1;13(8):2677-2682. https://doi.org/10.1021/acs.molpharmaceut.6b00240
Chu, Yu Hsuan ; Sibrian-Vazquez, Martha ; Escobedo, Jorge O. ; Phillips, Amanda R. ; Dickey, D. Thomas ; Wang, Qi ; Ralle, Martina ; Steyger, Peter ; Strongin, Robert M. / Systemic Delivery and Biodistribution of Cisplatin in Vivo. In: Molecular Pharmaceutics. 2016 ; Vol. 13, No. 8. pp. 2677-2682.
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