Systemic Delivery and Biodistribution of Cisplatin in Vivo

Yu Hsuan Chu; Martha Sibrian-Vazquez; Jorge O. Escobedo; Amanda R. Phillips; D. Thomas Dickey; Qi Wang; Martina Ralle; Peter S. Steyger; Robert M. Strongin

doi:10.1021/acs.molpharmaceut.6b00240

Systemic Delivery and Biodistribution of Cisplatin in Vivo

Yu Hsuan Chu, Martha Sibrian-Vazquez, Jorge O. Escobedo, Amanda R. Phillips, D. Thomas Dickey, Qi Wang, Martina Ralle, Peter S. Steyger, Robert M. Strongin

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

Original language	English (US)
Pages (from-to)	2677-2682
Number of pages	6
Journal	Molecular Pharmaceutics
Volume	13
Issue number	8
DOIs	https://doi.org/10.1021/acs.molpharmaceut.6b00240
State	Published - Aug 1 2016

Keywords

Texas Red
cisplatin
conjugate
ototoxicity
tracer

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

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10.1021/acs.molpharmaceut.6b00240

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abstract = "Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.",

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AU - Sibrian-Vazquez, Martha

AU - Escobedo, Jorge O.

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AU - Dickey, D. Thomas

AU - Wang, Qi

AU - Ralle, Martina

AU - Steyger, Peter S.

AU - Strongin, Robert M.

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AB - Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

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KW - tracer

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Systemic Delivery and Biodistribution of Cisplatin in Vivo

Abstract

Keywords

ASJC Scopus subject areas

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