Systemic Delivery and Biodistribution of Cisplatin in Vivo

Yu Hsuan Chu, Martha Sibrian-Vazquez, Jorge O. Escobedo, Amanda R. Phillips, D. Thomas Dickey, Qi Wang, Martina Ralle, Peter Steyger, Robert M. Strongin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

Original languageEnglish (US)
Pages (from-to)2677-2682
Number of pages6
JournalMolecular Pharmaceutics
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • cisplatin
  • conjugate
  • ototoxicity
  • Texas Red
  • tracer

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

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    Chu, Y. H., Sibrian-Vazquez, M., Escobedo, J. O., Phillips, A. R., Dickey, D. T., Wang, Q., Ralle, M., Steyger, P., & Strongin, R. M. (2016). Systemic Delivery and Biodistribution of Cisplatin in Vivo. Molecular Pharmaceutics, 13(8), 2677-2682. https://doi.org/10.1021/acs.molpharmaceut.6b00240