Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells

Hongzhe Li, Peter Steyger

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predominant compared to uptake via hair cell basolateral membranes during perilymph infusion.

Original languageEnglish (US)
Article number159
JournalScientific Reports
Volume1
DOIs
StatePublished - 2011

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Auditory Hair Cells
Endolymph
Aminoglycosides
Perilymph
Inner Ear
Cell Membrane
Anti-Bacterial Agents
Membranes

ASJC Scopus subject areas

  • General

Cite this

Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. / Li, Hongzhe; Steyger, Peter.

In: Scientific Reports, Vol. 1, 159, 2011.

Research output: Contribution to journalArticle

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