Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells

Hongzhe Li, Peter S. Steyger

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predominant compared to uptake via hair cell basolateral membranes during perilymph infusion.

Original languageEnglish (US)
Article number159
JournalScientific Reports
Volume1
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

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