Systematic review and meta-analysis of postexposure prophylaxis for crimean-congo hemorrhagic fever virus among healthcare workers

Önder Ergönül, Şiran Keske, Melis Gökçe Çeldir, İlayda Arjen Kara, Natalia Pshenichnaya, Gulzhan Abuova, Lucille Blumberg, Mehmet Gonen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0–0.03), and ribavirin use ≤48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0–0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection.

Original languageEnglish (US)
Pages (from-to)1642-1648
Number of pages7
JournalEmerging Infectious Diseases
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

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Crimean-Congo hemorrhagic fever virus
Ribavirin
Meta-Analysis
Virus Diseases
Delivery of Health Care
Odds Ratio
Infection
Nurses
Physicians
Therapeutics

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Systematic review and meta-analysis of postexposure prophylaxis for crimean-congo hemorrhagic fever virus among healthcare workers. / Ergönül, Önder; Keske, Şiran; Çeldir, Melis Gökçe; Kara, İlayda Arjen; Pshenichnaya, Natalia; Abuova, Gulzhan; Blumberg, Lucille; Gonen, Mehmet.

In: Emerging Infectious Diseases, Vol. 24, No. 9, 01.09.2018, p. 1642-1648.

Research output: Contribution to journalArticle

Ergönül, Önder ; Keske, Şiran ; Çeldir, Melis Gökçe ; Kara, İlayda Arjen ; Pshenichnaya, Natalia ; Abuova, Gulzhan ; Blumberg, Lucille ; Gonen, Mehmet. / Systematic review and meta-analysis of postexposure prophylaxis for crimean-congo hemorrhagic fever virus among healthcare workers. In: Emerging Infectious Diseases. 2018 ; Vol. 24, No. 9. pp. 1642-1648.
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