Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

Ozgun Babur, Mithat Gönen, Bülent Arman Aksoy, Nikolaus Schultz, Giovanni Ciriello, Chris Sander, Emek Demir

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.

Original languageEnglish (US)
Article number45
JournalGenome Biology
Volume16
Issue number1
DOIs
StatePublished - Feb 26 2015
Externally publishedYes

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cancer
genomics
neoplasms
gene
Genes
Neoplasms
genes
Genomics
methodology
testing
method
effect
test
Datasets

ASJC Scopus subject areas

  • Cell Biology
  • Ecology, Evolution, Behavior and Systematics
  • Genetics

Cite this

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations. / Babur, Ozgun; Gönen, Mithat; Aksoy, Bülent Arman; Schultz, Nikolaus; Ciriello, Giovanni; Sander, Chris; Demir, Emek.

In: Genome Biology, Vol. 16, No. 1, 45, 26.02.2015.

Research output: Contribution to journalArticle

Babur, Ozgun ; Gönen, Mithat ; Aksoy, Bülent Arman ; Schultz, Nikolaus ; Ciriello, Giovanni ; Sander, Chris ; Demir, Emek. / Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations. In: Genome Biology. 2015 ; Vol. 16, No. 1.
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