Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

Ozgun Babur, Mithat Gönen, Bülent Arman Aksoy, Nikolaus Schultz, Giovanni Ciriello, Chris Sander, Emek Demir

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.

Original languageEnglish (US)
Article number45
JournalGenome Biology
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 26 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology
  • Ecology, Evolution, Behavior and Systematics
  • Genetics

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