TY - JOUR
T1 - System dynamics modeling for traumatic brain injury
T2 - Mini-review of applications
AU - Kenzie, Erin S.
AU - Parks, Elle L.
AU - Carney, Nancy
AU - Wakeland, Wayne
N1 - Publisher Copyright:
Copyright © 2022 Kenzie, Parks, Carney and Wakeland.
PY - 2022/8/12
Y1 - 2022/8/12
N2 - Traumatic brain injury (TBI) is a highly complex phenomenon involving a cascade of disruptions across biomechanical, neurochemical, neurological, cognitive, emotional, and social systems. Researchers and clinicians urgently need a rigorous conceptualization of brain injury that encompasses nonlinear and mutually causal relations among the factors involved, as well as sources of individual variation in recovery trajectories. System dynamics, an approach from systems science, has been used for decades in fields such as management and ecology to model nonlinear feedback dynamics in complex systems. In this mini-review, we summarize some recent uses of this approach to better understand acute injury mechanisms, recovery dynamics, and care delivery for TBI. We conclude that diagram-based approaches like causal-loop diagramming have the potential to support the development of a shared paradigm of TBI that incorporates social support aspects of recovery. When developed using adequate data from large-scale studies, simulation modeling presents opportunities for improving individualized treatment and care delivery.
AB - Traumatic brain injury (TBI) is a highly complex phenomenon involving a cascade of disruptions across biomechanical, neurochemical, neurological, cognitive, emotional, and social systems. Researchers and clinicians urgently need a rigorous conceptualization of brain injury that encompasses nonlinear and mutually causal relations among the factors involved, as well as sources of individual variation in recovery trajectories. System dynamics, an approach from systems science, has been used for decades in fields such as management and ecology to model nonlinear feedback dynamics in complex systems. In this mini-review, we summarize some recent uses of this approach to better understand acute injury mechanisms, recovery dynamics, and care delivery for TBI. We conclude that diagram-based approaches like causal-loop diagramming have the potential to support the development of a shared paradigm of TBI that incorporates social support aspects of recovery. When developed using adequate data from large-scale studies, simulation modeling presents opportunities for improving individualized treatment and care delivery.
KW - complexity
KW - modeling
KW - simulation
KW - system dynamics
KW - systems science
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85136780946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136780946&partnerID=8YFLogxK
U2 - 10.3389/fbioe.2022.854358
DO - 10.3389/fbioe.2022.854358
M3 - Review article
AN - SCOPUS:85136780946
SN - 2296-4185
VL - 10
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
M1 - 854358
ER -