Syphilitic hepatitis resulting in fulminant hepatic failure requiring liver transplantation

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Abstract

Syphilitic hepatitis is a rare but well described syndrome, typically manifesting as a mild clinical hepatitis, with complete resolution following therapy. There have been several cases of severe hepatitis, but none progressing to a fatal outcome. We present a case of fulminant hepatitis and hepatic failure in the setting of active secondary syphilis resulting in liver transplantation. The clinical syndrome of syphilitic hepatitis is discussed. This case should highlight and remind physicians of the varied and severe manifestations of syphilis, and prompt physicians to explore syphilis as a possible cause of unexplained hepatitis.

Original languageEnglish (US)
JournalJournal of Infection
Volume54
Issue number3
DOIs
StatePublished - Mar 2007

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Acute Liver Failure
Liver Transplantation
Hepatitis
Syphilis
Physicians
Fatal Outcome

Keywords

  • Acute
  • Hepatitis
  • Liver failure
  • Liver transplantation
  • Syphilis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

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title = "Syphilitic hepatitis resulting in fulminant hepatic failure requiring liver transplantation",
abstract = "Syphilitic hepatitis is a rare but well described syndrome, typically manifesting as a mild clinical hepatitis, with complete resolution following therapy. There have been several cases of severe hepatitis, but none progressing to a fatal outcome. We present a case of fulminant hepatitis and hepatic failure in the setting of active secondary syphilis resulting in liver transplantation. The clinical syndrome of syphilitic hepatitis is discussed. This case should highlight and remind physicians of the varied and severe manifestations of syphilis, and prompt physicians to explore syphilis as a possible cause of unexplained hepatitis.",
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AU - Lo, Jamie

AU - Harrison, Rebecca

AU - Hunter, Alan

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AB - Syphilitic hepatitis is a rare but well described syndrome, typically manifesting as a mild clinical hepatitis, with complete resolution following therapy. There have been several cases of severe hepatitis, but none progressing to a fatal outcome. We present a case of fulminant hepatitis and hepatic failure in the setting of active secondary syphilis resulting in liver transplantation. The clinical syndrome of syphilitic hepatitis is discussed. This case should highlight and remind physicians of the varied and severe manifestations of syphilis, and prompt physicians to explore syphilis as a possible cause of unexplained hepatitis.

KW - Acute

KW - Hepatitis

KW - Liver failure

KW - Liver transplantation

KW - Syphilis

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JO - Journal of Infection

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