@article{5d154ce139b648d3902d3b1f65287b70,
title = "Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides",
abstract = "The synthesis of novel pyrazolylnucleosides 3a–e, 4a–e, 5a–e, and 6a–e are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5a–e and 6a–e were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI50 9.3 µM) and breast cancer cell line HS 578T (GI50 3.0 µM).",
keywords = "Anticancer, Modified nucleosides, NCI-60, NOESY study, Pyrazolylnucleosides",
author = "Yogesh Yadav and Deepti Sharma and Kumar Kaushik and Vineet Kumar and Amitabh Jha and Prasad, {Ashok K.} and Christophe Len and Malhotra, {Sanjay V.} and Jesper Wengel and Parmar, {Virinder S.}",
note = "Funding Information: 1 Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India; yogeshyadav77@gmail.com (Y.Y.); sharma81deepti@gmail.com (D.S.); iamvineet@gmail.com (V.K.); ashokenzyme@gmail.com (A.K.P.) 2 Medicinal Chemistry Laboratory, Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6, Canada; amitabh.jha@acadiau.ca 3 SUN Pharmaceuticals R&D, Gurgaon, Sarhaul, Sector-18, Haryana-122 015, India 4 Sri Venkateswara College, Benito Juarez Road, Dhaula Kuan, University of Delhi, Delhi 110 021, India 5 Department of Chemistry and Environmental Science, Medgar Evers College, The City University of New York, 1638 Bedford Avenue, Brooklyn, NY 11225, USA; kumar.kaushik.drdo@gmail.com 6 Laboratory of Synthetic Chemistry, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 2170, USA; smalhotra@stanford.edu 7 Department of Radiation Oncology, Stanford University, 1050A Arastradero Road, A252, Palo Alto, CA 94304, USA 8 Chimie ParisTech, PSL University, CNRS Institute of Chemistry for Life and Health Sciences—i-CLeHS, 11 rue Pierre et Marie Curie, F-75005 Paris, France 9 Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark; jwe@sdu.dk Funding Information: Acknowledgments: We would like to thank the Department of Biotechnology (DBT, Govt. of India, New Delhi), the University of Delhi (DU, India), and the Nucleic Acid Center (NAC, University of Southern Denmark, Odense, Denmark) for their financial assistance. The authors are grateful to Dr. Carl-Erik Olsen, University of Copenhagen, Denmark for carrying out extensive NMR spectral studies and to Dr. Eric De Clercq, Rega Institute for Medical Research, K.U. Leuven, Belgium for carrying out the antiviral evaluation studies. Funding Information: We would like to thank the Department of Biotechnology (DBT, Govt. of India, New Delhi), the University of Delhi (DU, India), and the Nucleic Acid Center (NAC, University of Southern Denmark, Odense, Denmark) for their financial assistance. The authors are grateful to Dr. Carl-Erik Olsen, University of Copenhagen, Denmark for carrying out extensive NMR spectral studies and to Dr. Eric De Clercq, Rega Institute for Medical Research, K.U. Leuven, Belgium for carrying out the antiviral evaluation studies. Publisher Copyright: {\textcopyright} 2019 by the authors. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
doi = "10.3390/molecules24213922",
language = "English (US)",
volume = "24",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "21",
}