Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides

Yogesh Yadav, Deepti Sharma, Kumar Kaushik, Vineet Kumar, Amitabh Jha, Ashok K. Prasad, Christophe Len, Sanjay V. Malhotra, Jesper Wengel, Virinder S. Parmar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The synthesis of novel pyrazolylnucleosides 3a–e, 4a–e, 5a–e, and 6a–e are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5a–e and 6a–e were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI50 9.3 µM) and breast cancer cell line HS 578T (GI50 3.0 µM).

Original languageEnglish (US)
Article number3922
JournalMolecules
Volume24
Issue number21
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Anticancer
  • Modified nucleosides
  • NCI-60
  • NOESY study
  • Pyrazolylnucleosides

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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