Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive β-endorphin/β-lipotropin and ACTH by human fetal pituitaries in vitro

D. M. Gibbs; R. D. Stewart; W. Vale; J. Rivier; S. S.C. Yen

doi:10.1016/0024-3205(83)90150-9

Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive β-endorphin/β-lipotropin and ACTH by human fetal pituitaries in vitro

D. M. Gibbs, R. D. Stewart, W. Vale, J. Rivier, S. S.C. Yen

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive β-endorphin/β-LPH (iβ-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.

Original language	English (US)
Pages (from-to)	547-550
Number of pages	4
Journal	Life Sciences
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(83)90150-9
State	Published - Jan 31 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive β-endorphin/β-lipotropin and ACTH by human fetal pituitaries in vitro",

abstract = "Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive β-endorphin/β-LPH (iβ-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.",

author = "Gibbs, {D. M.} and Stewart, {R. D.} and W. Vale and J. Rivier and Yen, {S. S.C.}",

note = "Funding Information: This work was supported in part by grants from the Rockefeller and Mellon Foundations. Permission to use fetal material was obtained from the UCSD Human Subjects Committee. The authors would like to thank D. Crowe for assistance in preparing the manuscript.",

year = "1983",

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T1 - Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive β-endorphin/β-lipotropin and ACTH by human fetal pituitaries in vitro

AU - Gibbs, D. M.

AU - Stewart, R. D.

AU - Vale, W.

AU - Rivier, J.

AU - Yen, S. S.C.

N1 - Funding Information: This work was supported in part by grants from the Rockefeller and Mellon Foundations. Permission to use fetal material was obtained from the UCSD Human Subjects Committee. The authors would like to thank D. Crowe for assistance in preparing the manuscript.

PY - 1983/1/31

Y1 - 1983/1/31

N2 - Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive β-endorphin/β-LPH (iβ-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.

AB - Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive β-endorphin/β-LPH (iβ-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.

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Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive β-endorphin/β-lipotropin and ACTH by human fetal pituitaries in vitro

Abstract

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