Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive β-endorphin/β-lipotropin and ACTH by human fetal pituitaries in vitro

D. M. Gibbs, R. D. Stewart, W. Vale, J. Rivier, S. S.C. Yen

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive β-endorphin/β-LPH (iβ-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalLife Sciences
Volume32
Issue number5
DOIs
StatePublished - Jan 31 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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