Synthesis of tritiated diborane and cryptand [2.2.2]

K. Garmestani, Jeanne Link, Kenneth Krohn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to provide a method for in vivo and in vitro detection of cryptand [2.2.2], tritiated cryptand was synthesized by reduction of appropriate bicyclic diamide with tritiated diborane. As part of this synthesis, tritiated diborane was synthesized by the reaction of tritiated sodium borohydride with boron trifluoride etherate and trapped in dry THF. This is a potentially useful agent for selective tritiation of molecules with functional groups which are prone to electrophilic attack.

Original languageEnglish (US)
Pages (from-to)1171-1178
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume28
Issue number10
StatePublished - 1990
Externally publishedYes

Fingerprint

Diamide
Functional groups
Molecules
cryptand
diborane
boron trifluoride etherate
sodium borohydride
In Vitro Techniques

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Synthesis of tritiated diborane and cryptand [2.2.2]. / Garmestani, K.; Link, Jeanne; Krohn, Kenneth.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 28, No. 10, 1990, p. 1171-1178.

Research output: Contribution to journalArticle

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