Synthesis of tritiated diborane and cryptand [2.2.2]

Kayhan Garmestani, Jeanne M. Link, Kenneth A. Krohn

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In order to provide a method for in vivo and in vitro detection of cryptand [2.2.2], tritiated cryptand was synthesized by reduction of appropriate bicyclic diamide with tritiated diborane. As part of this synthesis, tritiated diborane was synthesized by the reaction of tritiated sodium borohydride with boron trifluoride etherate and trapped in dry THF. This is a potentially useful agent for selective tritiation of molecules with functional groups which are prone to electrophilic attack.

Original languageEnglish (US)
Pages (from-to)1171-1178
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume28
Issue number10
DOIs
StatePublished - Oct 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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