TY - JOUR
T1 - Synthesis of [125I]-, [2H]-, and [ 3H]-labeled 3-iodothyronamine (T1AM)
AU - Miyakawa, Motonori
AU - Scanlan, Thomas
PY - 2006/3/9
Y1 - 2006/3/9
N2 - 3-Iodothyronamine (T1AM) is a novel metabolite of thyroid hormone. In HEK-293 cells expressing an orphan G-protein coupled receptor, the trace amine receptor, T1AM, potently increased cAMP accumulation. In mice, T1AM rapidly induced hypothermia and bradycardia within minutes of administration. These results suggest the existence of a new signaling pathway, the stimulation of which leads to rapid physiological and behavioral consequences. Isotope-labeled T1AM derivatives would be useful to study the biology and pharmacology of T1AM. Herein we describe efficient syntheses of [125I]-, [2H]-, and [ 3H]-T1AM.
AB - 3-Iodothyronamine (T1AM) is a novel metabolite of thyroid hormone. In HEK-293 cells expressing an orphan G-protein coupled receptor, the trace amine receptor, T1AM, potently increased cAMP accumulation. In mice, T1AM rapidly induced hypothermia and bradycardia within minutes of administration. These results suggest the existence of a new signaling pathway, the stimulation of which leads to rapid physiological and behavioral consequences. Isotope-labeled T1AM derivatives would be useful to study the biology and pharmacology of T1AM. Herein we describe efficient syntheses of [125I]-, [2H]-, and [ 3H]-T1AM.
KW - 3-Iodothyronamine (TAM)
KW - [H]-TAM
KW - [H]-TAM
KW - [I]-TAM
UR - http://www.scopus.com/inward/record.url?scp=33644646865&partnerID=8YFLogxK
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U2 - 10.1080/00397910500466074
DO - 10.1080/00397910500466074
M3 - Article
AN - SCOPUS:33644646865
VL - 36
SP - 891
EP - 902
JO - Synthetic Communications
JF - Synthetic Communications
SN - 0039-7911
IS - 7
ER -