Abstract
3-Iodothyronamine (T1AM) is a novel metabolite of thyroid hormone. In HEK-293 cells expressing an orphan G-protein coupled receptor, the trace amine receptor, T1AM, potently increased cAMP accumulation. In mice, T1AM rapidly induced hypothermia and bradycardia within minutes of administration. These results suggest the existence of a new signaling pathway, the stimulation of which leads to rapid physiological and behavioral consequences. Isotope-labeled T1AM derivatives would be useful to study the biology and pharmacology of T1AM. Herein we describe efficient syntheses of [125I]-, [2H]-, and [ 3H]-T1AM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 891-902 |
| Number of pages | 12 |
| Journal | Synthetic Communications |
| Volume | 36 |
| Issue number | 7 |
| DOIs | |
| State | Published - Mar 9 2006 |
Keywords
- 3-Iodothyronamine (TAM)
- [H]-TAM
- [H]-TAM
- [I]-TAM
ASJC Scopus subject areas
- Organic Chemistry
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Cite this
Miyakawa, M., & Scanlan, T. (2006). Synthesis of [125I]-, [2H]-, and [ 3H]-labeled 3-iodothyronamine (T1AM). Synthetic Communications, 36(7), 891-902. https://doi.org/10.1080/00397910500466074