Synthesis of nucleoside-based antiviral drugs in ionic liquids

Vineet Kumar; Sanjay V. Malhotra

doi:10.1016/j.bmcl.2008.08.090

Synthesis of nucleoside-based antiviral drugs in ionic liquids

Vineet Kumar, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.

Original language	English (US)
Pages (from-to)	5640-5642
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2008.08.090
State	Published - Oct 15 2008
Externally published	Yes

Keywords

Antiviral drugs
HIV
HSV
Ionic liquid
Nucleoside

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.08.090

Cite this

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title = "Synthesis of nucleoside-based antiviral drugs in ionic liquids",

abstract = "Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.",

keywords = "Antiviral drugs, HIV, HSV, Ionic liquid, Nucleoside",

author = "Vineet Kumar and Malhotra, {Sanjay V.}",

note = "Funding Information: This project was funded by NCI Contract N01-CO-12400. ",

year = "2008",

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doi = "10.1016/j.bmcl.2008.08.090",

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T1 - Synthesis of nucleoside-based antiviral drugs in ionic liquids

AU - Kumar, Vineet

AU - Malhotra, Sanjay V.

N1 - Funding Information: This project was funded by NCI Contract N01-CO-12400.

PY - 2008/10/15

Y1 - 2008/10/15

N2 - Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.

AB - Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.

KW - Antiviral drugs

KW - HIV

KW - HSV

KW - Ionic liquid

KW - Nucleoside

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis of nucleoside-based antiviral drugs in ionic liquids

Abstract

Keywords

ASJC Scopus subject areas

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