Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Antonella Pepe; Michael Pamment; Gunda I. Georg; Sanjay V. Malhotra

doi:10.1021/jo102558u

Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Antonella Pepe, Michael Pamment, Gunda I. Georg, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

Original language	English (US)
Pages (from-to)	3527-3530
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	76
Issue number	9
DOIs	https://doi.org/10.1021/jo102558u
State	Published - May 6 2011
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo102558u

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title = "Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines",

abstract = "Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.",

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AU - Georg, Gunda I.

AU - Malhotra, Sanjay V.

PY - 2011/5/6

Y1 - 2011/5/6

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AB - Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

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Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Abstract

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