Synthesis of a sec-precursor and analogues of macrolactin A

Xiangshu Xiao; Shukun Li; Xuebin Yan; Xuejun Liu; Rui Xu; Donglu Bai

doi:10.1246/cl.2005.906

Synthesis of a sec-precursor and analogues of macrolactin A

Xiangshu Xiao, Shukun Li, Xuebin Yan, Xuejun Liu, Rui Xu, Donglu Bai

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

(Chemical Equation Presented) A highly convergent and efficient route to sec-precursor 26 of macrolactin A has been developed. In the synthesis, Wittig and Horner-Emmons reactions were utilized to construct the conjugated dienes and control the right configurations of E,Z-and E,E-dienes. The segment 2 and 3 were prepared from the known compound 4 and 15 respectively. The coupling of segments 2 and 3 proceeded in the presence of NaHMDS. The analogues 7 and 32 were synthesized by the same strategy.

Original language	English (US)
Pages (from-to)	906-907
Number of pages	2
Journal	Chemistry Letters
Volume	34
Issue number	7
DOIs	https://doi.org/10.1246/cl.2005.906
State	Published - Jul 5 2005
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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abstract = "(Chemical Equation Presented) A highly convergent and efficient route to sec-precursor 26 of macrolactin A has been developed. In the synthesis, Wittig and Horner-Emmons reactions were utilized to construct the conjugated dienes and control the right configurations of E,Z-and E,E-dienes. The segment 2 and 3 were prepared from the known compound 4 and 15 respectively. The coupling of segments 2 and 3 proceeded in the presence of NaHMDS. The analogues 7 and 32 were synthesized by the same strategy.",

author = "Xiangshu Xiao and Shukun Li and Xuebin Yan and Xuejun Liu and Rui Xu and Donglu Bai",

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T1 - Synthesis of a sec-precursor and analogues of macrolactin A

AU - Xiao, Xiangshu

AU - Li, Shukun

AU - Yan, Xuebin

AU - Liu, Xuejun

AU - Xu, Rui

AU - Bai, Donglu

PY - 2005/7/5

Y1 - 2005/7/5

N2 - (Chemical Equation Presented) A highly convergent and efficient route to sec-precursor 26 of macrolactin A has been developed. In the synthesis, Wittig and Horner-Emmons reactions were utilized to construct the conjugated dienes and control the right configurations of E,Z-and E,E-dienes. The segment 2 and 3 were prepared from the known compound 4 and 15 respectively. The coupling of segments 2 and 3 proceeded in the presence of NaHMDS. The analogues 7 and 32 were synthesized by the same strategy.

AB - (Chemical Equation Presented) A highly convergent and efficient route to sec-precursor 26 of macrolactin A has been developed. In the synthesis, Wittig and Horner-Emmons reactions were utilized to construct the conjugated dienes and control the right configurations of E,Z-and E,E-dienes. The segment 2 and 3 were prepared from the known compound 4 and 15 respectively. The coupling of segments 2 and 3 proceeded in the presence of NaHMDS. The analogues 7 and 32 were synthesized by the same strategy.

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JO - Chemistry Letters

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Synthesis of a sec-precursor and analogues of macrolactin A

Abstract

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