Synthesis of a sec-precursor and analogues of macrolactin A

Xiangshu Xiao, Shukun Li, Xuebin Yan, Xuejun Liu, Rui Xu, Donglu Bai

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4 Citations (Scopus)

Abstract

(Chemical Equation Presented) A highly convergent and efficient route to sec-precursor 26 of macrolactin A has been developed. In the synthesis, Wittig and Horner-Emmons reactions were utilized to construct the conjugated dienes and control the right configurations of E,Z-and E,E-dienes. The segment 2 and 3 were prepared from the known compound 4 and 15 respectively. The coupling of segments 2 and 3 proceeded in the presence of NaHMDS. The analogues 7 and 32 were synthesized by the same strategy.

Original languageEnglish (US)
Pages (from-to)906-907
Number of pages2
JournalChemistry Letters
Volume34
Issue number7
DOIs
StatePublished - Jul 5 2005
Externally publishedYes

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macrolactin A

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Cite this

Synthesis of a sec-precursor and analogues of macrolactin A. / Xiao, Xiangshu; Li, Shukun; Yan, Xuebin; Liu, Xuejun; Xu, Rui; Bai, Donglu.

In: Chemistry Letters, Vol. 34, No. 7, 05.07.2005, p. 906-907.

Research output: Contribution to journalArticle

Xiao, X, Li, S, Yan, X, Liu, X, Xu, R & Bai, D 2005, 'Synthesis of a sec-precursor and analogues of macrolactin A', Chemistry Letters, vol. 34, no. 7, pp. 906-907. https://doi.org/10.1246/cl.2005.906
Xiao, Xiangshu ; Li, Shukun ; Yan, Xuebin ; Liu, Xuejun ; Xu, Rui ; Bai, Donglu. / Synthesis of a sec-precursor and analogues of macrolactin A. In: Chemistry Letters. 2005 ; Vol. 34, No. 7. pp. 906-907.
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