Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Thanh Lam; Taotao Ling; Chinmay Chowdhury; Ta Hsiang Chao; F. R. Bahjat; G. K. Lloyd; Lyle L. Moldawer; Michael A. Palladino; Emmanuel A. Theodorakis

doi:10.1016/S0960-894X(03)00669-3

Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Thanh Lam, Taotao Ling, Chinmay Chowdhury, Ta Hsiang Chao, F. R. Bahjat, G. K. Lloyd, Lyle L. Moldawer, Michael A. Palladino, Emmanuel A. Theodorakis

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.

Original language	English (US)
Pages (from-to)	3217-3221
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(03)00669-3
State	Published - Oct 16 2003
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents",

abstract = "The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.",

author = "Thanh Lam and Taotao Ling and Chinmay Chowdhury and Chao, {Ta Hsiang} and Bahjat, {F. R.} and Lloyd, {G. K.} and Moldawer, {Lyle L.} and Palladino, {Michael A.} and Theodorakis, {Emmanuel A.}",

note = "Funding Information: We thank the UC Discovery Program (#01-10222) and Nereus Pharmaceuticals, Inc. for financial support. ",

year = "2003",

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doi = "10.1016/S0960-894X(03)00669-3",

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TY - JOUR

T1 - Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

AU - Lam, Thanh

AU - Ling, Taotao

AU - Chowdhury, Chinmay

AU - Chao, Ta Hsiang

AU - Bahjat, F. R.

AU - Lloyd, G. K.

AU - Moldawer, Lyle L.

AU - Palladino, Michael A.

AU - Theodorakis, Emmanuel A.

N1 - Funding Information: We thank the UC Discovery Program (#01-10222) and Nereus Pharmaceuticals, Inc. for financial support.

PY - 2003/10/16

Y1 - 2003/10/16

N2 - The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.

AB - The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.

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U2 - 10.1016/S0960-894X(03)00669-3

DO - 10.1016/S0960-894X(03)00669-3

M3 - Article

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AN - SCOPUS:0041330429

SN - 0960-894X

VL - 13

SP - 3217

EP - 3221

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Abstract

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