Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Thanh Lam, Taotao Ling, Chinmay Chowdhury, Ta Hsiang Chao, Frances Bahjat, G. K. Lloyd, Lyle L. Moldawer, Michael A. Palladino, Emmanuel A. Theodorakis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.

Original languageEnglish (US)
Pages (from-to)3217-3221
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number19
DOIs
StatePublished - Oct 16 2003
Externally publishedYes

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Diterpenes
Esters
Anti-Inflammatory Agents
Cytokines
Cytotoxicity
acanthoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Lam, T., Ling, T., Chowdhury, C., Chao, T. H., Bahjat, F., Lloyd, G. K., ... Theodorakis, E. A. (2003). Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorganic and Medicinal Chemistry Letters, 13(19), 3217-3221. https://doi.org/10.1016/S0960-894X(03)00669-3

Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. / Lam, Thanh; Ling, Taotao; Chowdhury, Chinmay; Chao, Ta Hsiang; Bahjat, Frances; Lloyd, G. K.; Moldawer, Lyle L.; Palladino, Michael A.; Theodorakis, Emmanuel A.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 19, 16.10.2003, p. 3217-3221.

Research output: Contribution to journalArticle

Lam, T, Ling, T, Chowdhury, C, Chao, TH, Bahjat, F, Lloyd, GK, Moldawer, LL, Palladino, MA & Theodorakis, EA 2003, 'Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 19, pp. 3217-3221. https://doi.org/10.1016/S0960-894X(03)00669-3
Lam, Thanh ; Ling, Taotao ; Chowdhury, Chinmay ; Chao, Ta Hsiang ; Bahjat, Frances ; Lloyd, G. K. ; Moldawer, Lyle L. ; Palladino, Michael A. ; Theodorakis, Emmanuel A. / Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 19. pp. 3217-3221.
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