Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Thanh Lam, Taotao Ling, Chinmay Chowdhury, Ta Hsiang Chao, F. R. Bahjat, G. K. Lloyd, Lyle L. Moldawer, Michael A. Palladino, Emmanuel A. Theodorakis

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13 Scopus citations

Abstract

The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.

Original languageEnglish (US)
Pages (from-to)3217-3221
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number19
DOIs
StatePublished - Oct 16 2003

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Lam, T., Ling, T., Chowdhury, C., Chao, T. H., Bahjat, F. R., Lloyd, G. K., Moldawer, L. L., Palladino, M. A., & Theodorakis, E. A. (2003). Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorganic and Medicinal Chemistry Letters, 13(19), 3217-3221. https://doi.org/10.1016/S0960-894X(03)00669-3